e钙粘素在大鼠阿霉素肾病动物模型中表达及意义word格式论文.docxVIP

the occurrence can be seen focal glomerular sclerosis at the eighth week. 2. Compared with the control group, there were massive proteinuria in the adriamycin group , hypoalbuminemia, and the difference was statistically significant (p 0.01); The nephrophy group rats in the first 4 weeks the blood urea nitrogen and creatinine are no significant changes. At the end of the 6th week, the blood urea nitrogen and creatinine increased significangtly with the number of experimental week and showing a time-dependent manner. Up to maximum at the end of the 12th week, the difference was statistically significant (p 0.05).3.The histomorphology and pathology : In gross appearance, the glomeruler volume in control group is normal, dark red , cortical and juxtamedullary nephrons were separated clearly; and the glomeruler volume in the nephropathy group is slightly lager, dark red , cortical and juxtamedullary nephrons were also separated clearly. In electron microscopy, there was no change in the first 2 weeks in glomerular but only tubular fat degeneration. With disease progression cell swelling was significantly less than before, and small crescents have formated and the ball wall also havefibrosised. To the 8th week, we can observe mesangial cell mild proliferation, and some ratswith glomerular capillary loop with tubular atrophy and segmental sclerosis.The disease become more sever than before with increased progression.4.Immuno-histochemicaldetermination: ① the expression of E-cadherin: compared with the control group,nephropathy group E-cadherin expression in podocytes in glomeruli began to decrease at the 3rd week, and along with the time extension, the expression reduced gradually and at the12th week the expression was lowest and its difference significantly (p 0.01). ②Theexpression of MMP-9: MMP-9 expression was mainly located in the glomerular podocytes and endothelial cells; compared with the control group, the expression of