结直肠癌组织ets-1和mmp-9表达水平与肿瘤血管生成及恶性进展的关系-relationship between ets - 1 and mmp - 9 expression levels and tumor angiogenesis and malignant progression in colorectal cancer.docxVIP

华巾科大学闷济医学院硕士号业论文 移及病理分期密切相关Ets -1- MMP-9 、CD34 在淋巴结转移组、 Dukcs 分期 的 C 期和 D 期的表达分别显著高于无淋巴结转移组、队，，，分朔的 A 朔和自 剔， pO.OI 年龄51 岁组肝转移组中 Ets-1、酬p- 、CD31 显著商于年龄51 岁织、尤肝转移组 pO.0 1.Ets-j 与 MMP-9 在结直肠肿瘤中的表达 呈正相关什 =OH27p〈000. L结论(1) Ets-J 和刷P-9 均促迸绪皇后后肿瘤血管生成，并参与肿榴浸 润和淋巴道转移!与年龄及肝转移有关可作为监测结直局肿瘤预后的重安 指标(2)枪测 Ets-1 和 MMP-9的表达，可作为判定统直肠肿瘤血管形成、 浸润转移等生物学行为自J可拿指标， (3) 阻断 Ets-l 和协w←9 的合成分泌及作用途径，可作为结直局肿瘤的新的治疗手段。关键词转录调节因子 Ets-1基质金品缰白酶 9，结肠百肠肿瘤! 免疫组化1 血管形成2 华巾科性大学川挤医学院硕+毕业论文Relationship between expression of transcription factor Ets-l ，matrix metalloproteinase-gand angiogenesis and progressionin colorectal cancerDepartment of General Surgery ， Union Hospital of Tongji Medical College of Huazhong University of Science 时 TechnologyPoslgraduateFang Kuifeng Tutorhm1 XiansonABSTRACTObjective To Jnvestigale the expression of transcription factor F.ts-l (E26.-tnmsfol 皿丁。 n-specit?c- l) and 皿atrix metallooroteinaS l-9 (MMP-9) in colorlctal carcinorna and study their correlalion wi thangiog，mesis ，llJlllor infiltration and metastasisIfethods Tissue samples were collected from 11 patients who underwent surgery in our hospitaL At the same tirne ， 3 colorect 毡 lpnylps and 5 normal colorectal tissues were collected for control Immunohisl∞hümistry(SP kit) was used to detect the expression ()fEts-L MMP-9 and CD34 in these samples. The clinical pathological p，皿 ters wero analyzed at the s皿 time3 华中科技人?同济民学院倾 l 毕业论文Re8ul t8 ln normal coloroc1al li ssues and colorectal poy 1p 飞 Ets-l and MMP-!j pro t.ein can hHrdly be detecled ， but they ovorexpross in coloreclHl carcino且 ndls. Results rcvealed that p吨 ilive Ets-land MMP-9 exprossion and tho rn闹。 MVD value in 叫阿1ηm 王 tlssues were noticeably higher 让时且 that in thc normal tissues liJld colorectulpoylps ，pO.OI: that the MVD value in the Ets-l and MMP-9 ]Jositiveg叫was prorninently higher than that in Ets-l and 酬-9 叩tlVC group ，p 0. 01; that thc expressi on of Ets- J ，MMP