坎地沙坦干预大鼠动脉粥样硬化作用及机制的实验分析-experimental analysis of the intervention effect and mechanism of candesartan on atherosclerosis in rats.docx

AbstractD and E(P0.05). Compared with group B, the expressions of VEGF in aorta decreased in groups of C,D and E(P0.05).Conclusion:Candesartan can regulate the disorder of blood lipids and influence the morphology of artery in atherosclerosis rats.Candesartan can increase SOD and decrease MDA and oxLDL remarkably of blood serum in atherosclerosis rats.Candesartan appeares to markedly reduce the expressions of MMP-2 and VEGF of aorta in atherosclerosis rats.Key wordsatherosclerosisCandesartanblood lipidsoxidative stressMMP-2VEGF英文缩略词表英文缩略词表缩略词英文全称中文全称ASatherosclerosis动脉粥样硬化TCtotal cholesterol总胆固醇TGtriglyceride甘油三脂LDLlow density lipoprotein低密度脂蛋白HDLhigh density lipoprotein高密度脂蛋白 OxLDLoxidized low density lipoprotein氧化低密度脂蛋白 SODsuperoxide dismutase超氧化物歧化酶MDAmalondialdehyde丙二醛MMP-2matrix metalloproteinase-2基质金属蛋白酶 2VEGFvascular endothelial growth factor血管内皮生长因子LOX-1lectinlikeoxidizedlowdensity lipoprotein receptor-1凝 集 素 样 氧化 低 密 度 脂蛋白受体 1SRscavenger receptor清道夫受体NF-κBnuclear factor-κB核因子-κBMCP-1monocyte chemoattractant protein-1单核细胞趋化蛋白-1SMCsmooth muscle cell平滑肌细胞ARBangio-tensinⅡrecepter blockades血 管 紧 张 素Ⅱ 受 体 拮抗剂RT-PCReversetranscriptionpolymerase chain reaction反 转 录 聚 合酶 链 式 反应AngⅡangio-tensinⅡ血管紧张素ⅡTNFtumor necrosis factor肿瘤坏死因子英文缩略词表缩略词英文全称中文全称ROSreactive oxygen species活 性氧自 由基RNSreactive nitrogen species活 性氮自 由基NOnitric oxide一氧化氮AGEsadvanced glyeation end products晚 期 糖 基 化 终 末 产物DCsdendritic cells树突状细胞NADPHreducedformofnicotinamide-adenine dinucleotide phosphate还原型烟酰胺腺嘌呤 二核苷酸磷酸CVDcardiovascular diseases心血管疾病VCAM-1vascular cell adhesion molecule-1血管细胞粘附分子-1 ICAM-1intercellular adhesion molecule-1细胞间粘附分子-1 VLA-4very late antigen-4迟缓抗原-4ILInterleukin白细胞介素INFinterferon干扰素M-CSFmacrophage colony-stimulating factor巨噬细胞集落刺激因子G-CSFgranulocyte colony-stimulating factor粒细胞集落刺激因子PPARsperoxisome proliferators activated receptors过氧化物酶体增殖物激活受体MIFMigratory inhibitory factor游走抑制因子第一部分 文献综述第一部分文献综述综述一氧化低密度脂蛋白在动脉粥样硬化中的作用机制20 世纪 80 年代以来，动脉粥样硬化（AS）在全世界范围内已经成为心脑血管疾病 的最主要病因，并产生严重的后