临床-弥散加权成像不匹配与进展性脑梗死的相关性分析-correlation analysis between clinical - diffusion weighted imaging mismatch and progressive cerebral infarction.docxVIP
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临床-弥散加权成像不匹配与进展性脑梗死的相关性分析-correlation analysis between clinical - diffusion weighted imaging mismatch and progressive cerebral infarction
白原、血白细胞计数、总胆固醇及甘油三酯差异无统计学意义(P0.05);进展组患者空腹血糖高于非进展组,两组间差异有统计学意义(P0.01)。3、120例病人中符合临床-弥散加权成像不匹配(CDM)者有30例,其中进展组为17例(17/27,63.0%),而非进展组为13例(13/93,16.3%),差异有统计学意义(P0.001)。4、进展组27例患者中,侧脑室体旁梗死者8例(29.6%),分水岭梗死者9例(33.3%),脑叶梗死者5例(18.5%),基底节区梗死者3例(11.1%),大面积梗死者2例(7.4%);而非进展组93例患者中,侧脑室体旁梗死者13例(14.0%),分水岭区梗死者12例(12.9%),脑叶梗死者27例(29.0%),基底节区梗死者35例(37.6%),大面积梗死者6例(6.5%),梗死部位位于侧脑室体旁或分水岭区的患者进展性脑梗死发生率较高。5、进展组中,MRA显示的大脑中动脉狭窄或闭塞者11例(11/27,40.7%),非进展组为18例(18/93,19.4%),差异有统计学意义(P0.05)。6、Logistic回归分析显示,临床-弥散加权成像不匹配(CDM)、MRA显示的大脑中动脉狭窄或闭塞可能是进展性脑梗死的独立危险预测指标。结论1、入院后空腹血糖升高可能是进展性脑梗死发生的相关危险因素。2、进展组中侧脑室体旁或分水岭区脑梗死的出现率较高,入院时NIHSS评分也较高,可能对进展性脑梗死的发生有早期预警意义。3、通过临床-弥散加权成像不匹配、MRA显示的大脑中动脉狭窄或闭塞,可能是进展性脑梗死的有效预测指标。关键词进展性脑梗死;临床-弥散加权成像不匹配;大脑中动脉;梗死部位Studyonclinical-DWImismatchrelatedwithprogressivecerebralinfarctionABSTRACTObjectiveThemorbidityandmortalityratesofprogressivecerebralinfarctionarehigherthanordinaryinfarction,whichisoneoftheimportantreasonsthatcouldaffecttheprognosisofpatientsandalsothedifficultyofthepreventionandtreatment.Thisstudyistofindsomepossiblepredictiveandriskfactorsofprogressivecerebralinfarctionbycomparisonandanalysisoftheclinical-DWImismatch(CDM)andtheotherrelatedfactorsinpatientswithprogressivecerebralinfarction,whichcanprovidesomerelevantinformationsforclinicalearlydetection,preventionandtreatmentofprogressivecerebralinfarction.Methods120patientswithacutecerebralinfarctioninhospitalnomorethan24hourswereselected,fromJanuarytoSeptember2012,attheAffiliatedHospitalofNingxiaMedicalUniversityDepartmentofNeurology.Accordingtowhethercerebralinfarctionwereprogressedafteradmissionornot,thepatientsweredividedintoPCIgroup,27cases,andnon-progressiongroup,93cases.Thegeneralinformationofthebothgroupswerenoted,includingage,gender,historyofhypertension,diabetes,hyperlipemiaandsmoking;thelaboratoryindicatorswererecorded,includingtemperature,routinebloodtest,fastingglucose,triglyceride(TG),totalcholesterol(TC),fibrinogen(FIB);TheDiffusionWeightedImaging(DWI)hasbeenaccomplishedafteradmission,Accordingtot
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