阻塞性睡眠呼吸暂停低通气综合征患者认知功能和生活质量关系.docVIP

阻塞性睡眠呼吸暂停低通气综合征患者认知功能和生活质量关系 　　【摘 要】 目的：评估阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者生活质量和认知功能状况，探讨其与多导睡眠监测图（PSG）主要指标的关系。方法：选择2006年7月至2007年4月在兰州大学第一医院就诊经PSG确诊的62例OSAHS患者和32例非OSAHS患者（对照组），用生活质量自评量表、简易智能精神状态量表、Epworth嗜睡量表（ESS）进行评估。结果：OSAHS组生活质量、认知功能评分均低于对照组（63.9±14.7/78.8±4.5、24.6±2.0/27.1±1.3，P均?0.001）；生活质量与呼吸紊乱指数(AHI)、ESS呈负相关（r=-0.52、-0.39，P均 　　【关键词】睡眠呼吸暂停；阻塞性； 睡眠呼吸暂停综合征；认知障碍；生活质量；病例对照研究 　　中图分类号：R563.8、B842.1 文献标识码：A 文章编号：1000-6729(2008)002-0133-04 　　Relationship between Quality of Life and the Function of Cognition in Patients with 　　Obstructive Sleep Apnea-hypopnea Syndrome 　　YANG Shu-Kun, YU Qin, ZHANG Jia-Bin，et al. 　　Department of Respiratory Medicine, The First Hospital of Lanzhou University, Lanzhou 730000 　　【Abstract】 Objective：To assess the quality of life (QOL) and cognition function in patients with severe obstructive sleep apnea (OSAHS), and to study the relationship between the QOL and severity of OSAHS, excessive daytime sleepiness (EDS)，cognition disorders. Methods：Sixty-two patients with OSAHS and 32 non-OSAHS patients (control group) which all diagnosed by polysomnography (PSG) were chosen from The First Hospital of Lanzhou University, and they were assessed by QOL using the Short-Form 36 Health Survey questionnaire (SF-36), by EDS using the Epworth sleepiness scale (ESS), and for cognition disorders by mini-mental state examination (MMSE).The associations between the total score on the SF-36 and the baseline characteristics, PSG parameters, such as ESS score, and MMSE score were examined by simple regression analysis and stepwise multiple regression analysis.Results：The scores of SF-36 and MMSE in OSAHS group were significantly lower than the control group (63.9±14.7/78.8±4.5, 24.6±2.0/27.1±1.3,P 　　 　　1 对象和方法 　　 　　1.1 对象 　　选择2006年7月至2007年4月在本院就诊，有睡眠时打鼾、呼吸暂停、白天嗜睡等症状，经多导睡眠仪进行睡眠监测（Polysomnography，PSG）确诊的62例OSAHS男性患者。OSAHS诊断依据中华医学会呼吸病学分会睡眠呼吸疾病学组诊断标准［5］。同期选择在本院睡眠障碍门诊就诊，年龄、体重指数、受教育程度相匹配，PSG监测呼吸紊乱指数＜5的32例男性患者为对照组。OSAHS组和对照组受教育程度均在初中或初中以上；两组年龄、体重指数差异均无统