丙泊酚与七氟醚复合麻醉对肝炎肝硬化患者术后肝肾功能影响.docVIP

丙泊酚与七氟醚复合麻醉对肝炎肝硬化患者术后肝肾功能影响 　　[摘要] 目的 探讨丙泊酚与七氟醚复合麻醉对肝炎肝硬化术后患者肝肾功能的影响。 方法 研究对象为2008年5月～2010年9月我院收治的56例肝炎肝硬化行脾切断流术的患者，随机分为七氟醚组及丙泊酚+七氟醚组，每组28例。观察两组患者术前、麻醉诱导后2h、术后1d的肝肾功能指标及自由基水平。 结果 麻醉诱导后2h，两组ALB、SOD、MDA、BUN、Cr差异有统计学意义（P＜0.05）；术后1d，两组ALT、ALB、SOD、MDA、BUN、Cr差异有统计学意义（P＜0.05）。 结论 丙泊酚与七氟醚复合麻醉对肝炎肝硬化行脾切断流术患者的肝肾功能无显著不利影响，值得临床上推广应用。 　　[关键词] 丙泊酚；七氟醚；麻醉；肝炎肝硬化；肝肾功能 　　[中图分类号] R614 [文献标识码] B [文章编号] 1673-9701（2012）02-0078-03 　　 　　The effect of propofol combined with sevoflurane on renal and hepatic function in patients with liver cirrhosis 　　ZHANG Xuzhong 　　Department of Anesthesiology, The Third Affiliated Hospital of Wenzhou Medical College in Zhejiang Province, Ruian 325200, China 　　[Abstract] Objective To investigate the effect of propofol combined with sevoflurane on renal and hepatic function in 1iver cirrhosis patients． Methods Admitted to our hospital from may 2008 to september 2010, and comfirmed by porta-azygous disconnection，56 patients analyzed retrospectively. 56 patients with randomly divided into sevoflurane group and propofol+sevoflurane group.Renal and hepatic functions, oxygen free radicals level were detected before and on the 2 h after anesthesia induction and 1st postoperative day．Results On the 2 h after anesthesia induction, ALB, SOD, MDA, BUN, Cr were significantly different between the two groups(P＜0.05); On the 1st postoperative day, ALT, ALB, SOD, MDA, BUN, Cr were significantly different between the two groups(P＜0.05). Conclusion Propofol combined with sevoflurane has no significant effect on the renal and hepatic function in patients with liver cirrhosis underwent portaazygous disconnection, is worthy to be popularized． 　　[Key words] Propofol; Sevoflurane; Renal; Hepatic; Liver cirrhosis 　　 　　肝脏及肾脏是机体中非常重要的实质器官，在维持机体内环境稳定及调节新陈代谢中起重要作用，而麻醉药对肝脏及肾脏的影响始终为麻醉科医师所关注。本组研究对象为2008年5月～2010年9月我院收治的56例肝炎肝硬化行脾切断流术的患者，随机分为七氟醚组及丙泊酚+七氟醚组，每组28例。观察两组患者术前、麻醉诱导后2h、术后1d的肝肾功能指标及自由基水平，旨在通过探讨丙泊酚与七氟醚复合麻醉对肝炎肝硬化患者术后肝肾功能的影响，寻找一种比较适合、安全的麻醉方法。 　　 　　1 资料与方法 　　1.1 一般资料