不孕症患者子宫内膜mmp-9和timp-1表达水平的研究-study on the expression levels of mmp - 9 and timp - 1 in endometrium of infertility patients.docxVIP
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不孕症患者子宫内膜mmp-9和timp-1表达水平的研究-study on the expression levels of mmp - 9 and timp - 1 in endometrium of infertility patients
AbstractObjective:Tostudytheexpressionofmatrixmetalloproteinase-9(MMP-9)andtissueofmetalloproteinase-1(TIMP-1)intheendometriumofthesterilitypatientandnormalendometrium,andtoexplorethechangeofendometrialreceptivityofthesterilitypatient.Methods:EndometriumbiopsywasdoneinthethirtyPCOSpatientsreceivedovulationinductiontherapieswhoweredividedtosuccessedovulationgruoupandunsuccessedovulationgroup,nineteenoviductpathologicalchangesterilepatientsweredividedtotheoviductobstructiongroupandthehydrosalpinxgroupandthetennormalwomenwithregularmenstruationduringimplantingwindowtime.ImmunohistochemicalanalysiswasdeployedtodemonstratetheexpressionofMMP-9andTIMP-1inendometrium.Results:(1)TheexpressionoftheMMP-9andTIMP-1intheendometriumoftheobstructionoffallopiantubegroupissignificantlylowerthanthecontrolgroup(P0.05).(2)TheexpressionoftheMMP-9andTIMP-1intheendometriumofhydrosalpinxgroupissignificantlylowerthanthecontrolgroup(P0.05).(3)TheexpressionoftheMMP-9andTIMP-1intheendometriumofhydrosalpinxgroupissignificantlylowerthantheobstructionoffallopiantubegroup(P0.05).(4)TheexpressionofMMP-9andTIMP-1intheendometriumof15successedovulationPCOSwomenissignificantlylowerthanthecontrolgroup(P0.05)。(5)TheexpressionoftheexpressionofMMP-9andTIMP-1intheendometriumof15unsuccessedovulationPCOSwomenissignificantlylowerthanthecontrolgroup(P0.05)。(6)TheexpressionoftheMMP-9andTIMP-1intheendometriumof15unsuccessedovulationgroupissignificantlylowerthantheoneof15successedovulationgroup(P0.05).Conclusion:(1)MMP-9andTIMP-1weredetectedinendometriumofthePCOSPatients,theoviductinfertilitypatientsandthecontrolsduringimplantingwindowtime.(2)TheexpressionofMMP-9andTIMP-1inendometriumintheoviductinfertilitywomenissignificantlylowerthanthecontrolgroup.(3)TheexpressionofMMP-9andTIMP-1inendometriuminPCOSwomenissignificantlylowerthanthecontrolgroup.(4)ItindicatesthatMMPs/TIMPsmaybebiomakersofendometrialreceptivity.Keywords:polycysticovarysyndrometheimplantingwindowmatrixmetalloproteinasestheuterinereceptivity目录引言………………
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