法舒地尔对uuo大鼠模型ikkβ iκbα nf-κbp65 及iii型胶原表达的影响-effects of fasudil on ikk β i κ b α nf - κ bp65 and collagen iii expression in uuo rat model.docxVIP

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2018-05-29 发布于上海
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法舒地尔对uuo大鼠模型ikkβ iκbα nf-κbp65 及iii型胶原表达的影响-effects of fasudil on ikk β i κ b α nf - κ bp65 and collagen iii expression in uuo rat model.docx

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法舒地尔对uuo大鼠模型ikkβ iκbα nf-κbp65 及iii型胶原表达的影响-effects of fasudil on ikk β i κ b α nf - κ bp65 and collagen iii expression in uuo rat model

目录中文摘要··································································································1 英文摘要··································································································5 英文缩写································································································10 研究论文法舒地尔对 UUO 大鼠模型 IKKβ、IκBα、NF-κBP65 及 III 型胶原表达的影响························································11 前言·································································································11 材料与方法····················································································13 结果································································································20 附图································································································23 附表································································································36 讨论································································································39 结论································································································45 参考文献························································································46 综述 Rho 小 G 蛋白与肾间质纤维化的研究进展······························49 致谢········································································································57 个人简历································································································58法舒地尔对 UUO 大鼠模型 IKKβ、IκBα、NF-κBP65 及III 型胶原表达的影响摘要目的：肾间质纤维化是各种慢性肾脏疾病（ Chronic Kidney Disease，CKD）进行性进展的共同病理基础，其病理学变化是细胞外基质(extracellular matrix，ECM)的过多沉积，进而导致肾结构的破坏及肾功能的下降。多种细胞、细胞信号转导通路及细胞因子均参与该过程。肾间质纤维化的早期表现为以巨噬细胞、淋巴细胞等炎性细胞浸润，细胞因子、趋化因子增加为主的炎症状态。在炎症反应中产生的多种细胞因子、生长因子及趋化因子及均可作用于成纤维细胞（fibroblasts,FB）引起 FB 增生活跃以及诱导其发生表型转化，使其合成胶原蛋白能力增加，导致细胞外基质过度沉积，造成肾脏结构重塑，促进肾间质纤维化。核因子-κB（nuclear factor-κB，NF-κB）是一种很重要的转录因子，在各种细胞外刺激介导的细胞信号转导调控中起核心作用，研究发现多种细胞因子、生长因子及趋化因子的基因表达是通过该因子转录机制来调节的，在肾间质纤维化过程中，能促