糖尿病视网膜病变患者血清CAMS和脂联素水平分析.docVIP

糖尿病视网膜病变患者血清CAMS和脂联素水平分析 　　【摘要】 目的 分析糖尿病视网膜病变患者的血清细胞黏附分子（CAMS）和脂联素水平及相关性。 方法 采用放免法测定受试者血清脂联素水平，采用ELISA法检测血清sICAM-1和sICAM-1水平，同时测定体重指数（BMI）、血脂等指标。 结果 糖尿病视网膜病变组（DR）血清脂联素水平较DM组和NC组显著降低（P＜0.05 或＜0.01）；DR组血清sICAM-1、 sICAM-1水平高于DM组和NC组（P＜0.05或＜0.01）；血清脂联素水平与血清sICAM-1 、sICAM-1水平呈显著负相关（P均＜0.01）。结论 血清sICAM-1、sICAM-1以及脂联素参与了糖尿病视网膜病变的发生发展，脂联素可能通过抑制血sICAM-1、sICAM-1水平对DR起保护作用。 　　【关键词】 糖尿病视网膜病变；细胞黏附分子；脂联素? 　　文章编号：1003-1383(2007)06-0629-03中图分类号：R 587.2文献标识码：A? 　　 　　Serum cellular adhesion molecules level and adiponectin level in? 　　 patients with diabetic retinopathy 　　WAN Hui, YAO Wei?feng, QIAN Tie?yong? 　　（Department of Endocrinology, The Second Hospital of Wuxi, Wuxi，Jiangsu,214000）?? 　　 　　【Abstract】 Objective To explore the corelation of serum cellular adhesion molecules and serum adiponectin level in patients with diabetic retinopathy. 　　Methods To detect serum adiponectin with radioimmunoassay, serum sICAM1 and sICAM-1 with enzyme?linked immunoassay(ELISA). Some other index such asbody mass index(BMI),serum lipid were detected too. Results The level of serum adiponectin in diabetic retinopathy group (DR) was significantly lower than that in DM group and NC group（P＜0.05and P＜0.01）;the levels of serum sICAM-1 and sICAM-1 in DR group were significantly higher than those of DM group and NC group（P＜0.05 and P＜0.01）; The level of serum adiponectin was negatively correlated with the levels of serum sICAM-1 and sICAM-1（P＜0.01）.Conclusion Serum sICAM-1、sICAM-1 and adiponectin may participate in the onset and development of diabetic retinopathy, the adiponectin may protect DR by inhibiting the serum sICAM-1、sICAM-1. 　　?【Key words】 diabetic retinopathy; cell adhesion molecule; adiponectin? 　　 　　糖尿病视网膜病变是糖尿病最常见的微血管并发症之一，是成人首位致盲眼病，至今其发病机制尚未完全阐明。近年国内外大量研究发现，血管内皮细胞黏附表达增高与糖尿病视网膜病变（DR）形成有密切关系，细胞黏附分子（cellular adhesion molecules,CAMS）引起的内皮细胞损伤是糖尿病血管病变的早期病理性特征［1］。脂联素是脂肪细胞特异性分泌的一种蛋白质，近年来的研究认为，脂联素与肥胖、2型糖尿病、胰岛素抵抗及糖尿病大血管病变等都有相关性，而关于脂联素与糖尿病微血管病变之间的关系研究尚不多见。但新近研究发现脂联素在糖尿病视网膜病变中可能起调控作用