运动对糖尿病大鼠LPL和HL影响研究.docVIP

运动对糖尿病大鼠LPL和HL影响研究 　　摘要：研究运动对链脲佐菌素所致糖尿病大鼠LPL和HL的影响。分别将糖尿病大鼠和正常SD大鼠分为运动组和非运动组（每组10只），运动组进行10周的游泳训练。结果表明：1） 糖尿病大鼠较正常大鼠血糖、TG、和LDL明显升高，血清胰岛素、ISI和血浆中LPL活性降低（?P?＜0.05）；2） 糖尿病大鼠运动组较其非运动组血糖、TG、TC和LDL明显降低，血清胰岛素、血浆中LPL活性和HDL含量明显升高（?P?＜0.05）。提示，糖尿病机体LPL活性下降，血浆中富含TG的脂蛋白消除障碍，长期中等强度运动可以提高LPL的活性，进而降低TG水平，升高HDL，改善糖尿病机体的糖脂代谢，预防其慢性并发症的发生。? 　　关键词：糖尿病；运动；脂蛋白脂酶；肝脂酶? 　　中图分类号：G804.55文献标识码：A文章编号：1007-3612(2008)01-0047-03? 　　Effect of Exercise on LPL and HL Activities in STZ?Induced Diabetic Rats 　　? 　　WANG Yong?tao?1, JING Zhi?qiang?1, ZHANG Jun?2? 　　(1. Department of Physical Education, China Pharmaceutical University, Nanjing 210009, Jiangsu China; ?2. Institution of Human Kinesiology, Yangzhou University, Yangzhou 225009, Jiangsu China)? 　　Abstract:The effect of exercise on Lipoprotein Lipase（LPL）and Hepatic Lipase（HL）activities in Streptozotocin（STZ） which induced diabetic rats were investigated. Forty SD rats, including exercise STZ diabetic group, non?exercise STZ diabetic group, exercise normal group, and non?exercise normal group, were used in the study. Exercise groups were trained with swimming for ten weeks. Results are shown: 1） the blood glucose, triglyceride（TG）, and low?density lipoprotein（LDL）increased, while blood insulin, insulin sensitivity index（ISI）, and LPL activity decreased in diabetic group（?P?＜0.05）;2） after ten weeks of swimming exercise, LPL activity, blood insulin, ISI, and HDL in exercise diabetic rats was higher than that in non?exercise diabetic rats, while the blood glucose、TG、TC and LDL in exercisediabetic rats were lower than that in non?exercise diabetic rats（?P?＜0.05）. It is suggested that long?term moderate intensity exercise could improve lipid profile and prevent accident of chronic syndrome in diabetes by increasing LPL activity.? 　　Key words: diabetes mellitus;exercise;LPL;HL?? 　　脂蛋白脂酶（Lipoprotein lipase LPL）和肝脂???（Hepatic Lipase HL）是体内的两种脂酶，LPL可以水解乳糜微粒（CM）和极低密度脂蛋白（VLDL）中的甘油三脂（TG）；HL催化高密度脂蛋白（HDL）和中间密度脂蛋白（IDL）中TG的水解，促进IDL向LDL的转化。LPL的合成和分泌