Simplex Encephalitis University of Oklahoma 单纯疱疹病毒性脑炎俄克拉何马大学课件.pptVIP

Herpes Simplex Encephalitis Ellison D et al., 1998 Characteristic widespread, bilateral but asymmetrical involvement. Necrosis, particularly in the temporal lobe and the hippocampus. Cingulate gyrus may also be involved. The brain stem is rarely involved. Herpes Simplex Encephalitis Ellison D et al., 1998 Necrosis In situ hybridization EM Subacute or Chronic Viral Infection Subacute and Chronic Viral Infections General: They tend to progress slowly over months or years rather than weeks or days. The incubation period is often longer. Reactivation of a latent infection in an immunocompromised host is responsible in some of them. Virus type Disease . Measle virus Subacute sclerosing panencephalitis Measle virus Measle inclusion body encephalitis Rubella virus Progressive rubella panencephalitis JC virus Progressive multifocal leukoencephalopathy (PML) HIV HIV encephalitis, vacuolar myelopathy, etc. Human Immunodeficiency Virus (HIV) Ellison D et al., 1998 Microglial nodule Multinucleated giant cells Calcification Infections of the Central Nervous System Department of Pathology University of Oklahoma Health Sciences Center E. Stolzenberg, MD, PhD Objectives Describe the microscopic and macroscopic features of acute bacterial meningitis. Recognize the complications of bacterial meningitis. Identify the characteristics of tertiary syphilis. Name the common causes of fugal meningitis. Recognize the histopathologic features of herpes encephalitis. Parameters of CNS Infection Infectious agents: Bacteria, fungus, virus, protozoa, metazoa, prion. Mechanism: Acute, chronic, mixed, suppurative, abscess, granulomatous. Tissue involvement: Meningitis, meningoencephalitis, encephalitis, ventriculitis, etc. Distribution: Panencephalitis, rhombenencephalitis, poliomyelitis, etc. Route of entry: Blood, local infection, penetrating, contaminated surgical procedures (eg. VP-shunt), etc. Miscellaneous: Age