腺苷脱氨酶对结核性心包炎诊断价值Meta分析.docVIP

腺苷脱氨酶对结核性心包炎诊断价值Meta分析 　　【摘要】 目的：评估腺苷脱氨酶（ADA）对结核性心包炎的诊断价值。方法：检索Pubmed、Embase、CNKI、维普、万方等数据库，查找利用检测心包积液中ADA诊断结核性心包炎的文献。QUADAS工具评价纳入文献的质量。提取数据并利用Meta-Disc 1.4软件合并数据，计算纳入研究的合并敏感性、特异性等指标，绘制汇总受试者工作特征（SROC）曲线，综合评价ADA对结核性心包炎的诊断价值。结果：共有8篇文献共计716例研究对象纳入本次研究，meta分析显示ADA对结核性心包炎的合并诊断价值分别为：敏感度为0.88，特异度为0.87，阳性似然比为5.94，阴性似然比为0.13，诊断优势比为41.43。SROC曲线下面积为0.91。结论：检测心包积液中ADA对结核性心包炎具有较高的诊断价值。 　　【关键词】 腺苷脱氨酶； 结核性心包炎； Meta分析 　　Diagnostic Role of Adenosine Deaminase for Tuberculous Pericarditis： A Meta-analysis/YU Hua-xiang， LIU Yun-fang， XIANG Xue-li.//Medical Innovation of China，2013，10（26）：160-162 　　【Abstract】 Objective：To investigate the overall diagnostic role of adenosine deaminase （ADA） measurement for tuberculous pericarditis. Method：A systematic literature search was conducted in Pubmed， Embase， China National Knowledge Infrastructure databases，VIP Information， and WanFang Data to identify studies on evaluation of ADA in the diagnosis of tuberculous pericarditis.The methodological quality of included studies was evaluated by QUADAS tool. Data were retrieved and analyzed by using Meta-Disc 1.4 software. Sensitivity， specificity， and other measures of the accuracy of ADA in the diagnosis of tuberculous pericarditis were pooled. Summary receiver operating characteristic （SROC） curve was used to summarize the overall test performance. Result： Eight studies involving 716 subjects were included in the present meta-analysis. The summary estimates for ADA measurement in the diagnosis of tuberculous pericarditis were： sensitivity 0.88， specificity 0.87， positive likelihood ratio 5.94， negative likelihood ratio 0.13， diagnostic odds ratio 41.43， and the area under the SROC curve was 0.91. Conclusion： ADA measurement plays a valuable role in the diagnosis of tuberculous pericarditis. 　　【Key words】 Adenosine deaminase； Tuberculous pericarditis； Meta-analysis 　　First-author’s address：The People’s Hospital of Huili， Huili 615100，China 　　doi：10.3969/j.issn.1674-4985.2013.26.077 　　结核目前仍然