黛力新联合丁螺环酮治疗焦虑症伴发慢性主观性头晕疗效研究.docVIP

黛力新联合丁螺环酮治疗焦虑症伴发慢性主观性头晕疗效研究 　　摘要：目的观察黛力新联合丁螺环酮治疗焦虑症伴发慢性主观性头晕的疗效。方法将焦虑症伴发慢性主观性头晕患者随机分为研究组及对照组；对照组研究对象给予口服黛力新、谷维素片，研究组研究对象给予黛力新、丁螺环酮片。所有患者以服用12 w为观察终点。结果治疗12 w后两组头晕症状均有缓解，但研究组的临床痊愈率、显效率及总有效率均比对照组好。治疗4 w、8 w、12 w，研究组HAMILTON量表评分下降明显，有统计学意义（P　　关键词：慢性主观性头晕；焦虑症；黛力新；丁螺环酮 　　Study on the Effect of Deanxit Combined with Buspirone in the Treatment of Anxiety Disorders Associated with Chronic Subjectivity Dizziness 　　XIE Xue-jun1,ZHAO Yan-ru2,ZHAO Yan-ru1 　　(The Second Ward of the Department of Neurology，Affiliated Hospital of Chifeng College，Chifeng 024000，Inner Mongolia,China;2.Department of Neurology,Chifeng City Wengniute Banner Hospital,Chifeng 024000,Inner Mongolia,China) 　　Abstract：ObjectiveObservation of curative effect of Deanxit combined with buspirone in the treatment of anxiety disorders associated with chronic subjectivity dizziness. MethodsThe patients were randomly divided into experimental group and control group with anxiety associated with chronic dizziness; The control group were given deanxit combined with oryzanol ; the experimental group were received deanxit combined with buspirone; All patients were treated 12 weeks. ResultsAfter 12 weeks of treatment, two groups of dizziness symptoms were alleviated, but cure rate, marked effective rate and total effective rate of experimental group subjects were better than that of the control group. HAMILTON score of experimental group were significantly reduced than that of control group for 4 weeks, 8 weeks, 12 weeks(P14分。随机分为黛力新+谷维素组组和黛力新+丁螺环酮组。 　　1.2方法 对照组服用黛力新+谷维素片，研究组服用黛力新+丁螺环酮片，剂量分别为黛力新1片，1次/d，晨服（丹麦）；丁螺环酮 10 mg，3次/d，口服，(江苏恩华制药生产，商品名：一舒)，谷维素 2片，3次/d，口服，总疗程为12 w。有高血压、糖尿病、高脂血症者行降血压、降糖、调脂等相关治疗。 　　1.3检测项目及疗效评定 根据头晕改善程度分级。 0级：头晕全部消失；1级：经提示后仍感有头晕存在；2级：有比较明显的头晕，但日常生活、工作不受影响；3级：头晕明显且影响到日常生活和工作。临床痊愈：头晕症状全部消失；显效：原有症状改善2级以上；轻度缓解：原有症状改善1级；无效：症状无改善。有效率=（痊愈＋显效＋轻度缓解）/总例数×100%。HAMILTON焦虑量表在治疗前和治疗后第2 周末、4周末、8周末、12周末各评定1次。评价药品不良反应。 　　1.4统计学处理 所得数据应用SPSS13.0统计学软件处理，计量资料采用t 检验,以均数±标准差（x±s） 表示，计数资料采用χ2检验，P＜0.05 为差异有统计学。 　　2结果 　　2.1