LASS2Ki67表达与鼻咽癌复发相关性及其意义.docVIP

LASS2Ki67表达与鼻咽癌复发相关性及其意义 　　[摘要]目的 探讨LASS2及Ki67表达与鼻咽癌复发的相关性及其意义。方法 收集我院2011年～2014年的126例鼻咽癌活检标本，其中首发病例77例，复发病例49例。采用免疫?M织化学方法检测LASS2及Ki67在126例鼻咽癌活检组织中的表达，分析LASS2及Ki67在两组间的表达差异及其之间的相关性。结果 LASS2在复发病例中的阳性率为61.2%，低于首发病例的88.3%，差异有统计学意义（P0.05），但LASS2表达与Ki67表达相比较，差异有统计学意义（P0.05）。结论 LASS2在鼻咽癌复发的病例中呈低表达，检测LASS2蛋白可能有助于提示肿瘤是否容易复发，LASS2在预测鼻咽癌复发中可能具有重要的临床意义。LASS2与Ki67存在负相关，提示LASS2有可能抑制鼻咽癌肿瘤细胞的增殖。 　　[关键词]鼻咽癌；LASS2；Ki67；复发 　　[中图分类号] R739.62 [文献标识码] A [文章编号] 1674-4721（2017）10（c）-0120-03 　　Relationship between the expression of LASS2 and Ki67 with recurrent of nasopharyngeal carcinoma and its significance 　　WANG Jian-zhang HE Zhi-ming HUANG Jin-fen LI Wei-xia 　　Department of Pathology，Shunde Hospital of Guangzhou University of Traditional Chinese Medicine，Guangdong Province，Foshan 528333，China 　　[Abstract]Objective To investigate the relationship between LASS2 and Ki67 expression with the recurrent of nasopharyngeal carcinoma （NPC） and its significance.Methods A total of 126 cases of NPC biopsy specimens in our hospital from 2011 to 2014 were collected，including 77 initial cases and 49 recurrent cases.Immunohistochemical methods were used to detect the expression of LASS2 protein and Ki67 in 126 patients with NPC.The difference between the expression of LASS2 and Ki67 in the two groups and their correlation were analyzed.Results The positive rate of LASS2 in recurrent cases was 61.2%，which was lower than 88.3% of the initial cases，with significant difference （P0.05），however，there is a negative correlation between LASS2 expression and Ki67 （P0.05）.Conclusion LASS2 was low-expressed in the recurrence of NPC.Detection of LASS2 protein may help to prompt tumor recurrence.LASS2 may be a clinically significant biological indicator for predicting the recurrence of NPC.LASS2 is negatively correlated with Ki67.It is suggested that LASS2 may inhibit the proliferation of NPC tumor cells. 　　[Key words]Nasopharyngealcarcinoma；LASS2；Ki67；Recurrence 　　鼻咽癌是原发于鼻咽黏膜被覆上皮的恶性肿瘤，是我国常见的恶性肿瘤之一，发病率高