HPV 16,HPV 18,HSV2多重感染与宫颈癌相关性研究.docVIP

HPV 16,HPV 18,HSV2多重感染与宫颈癌相关性研究 　　[摘要] 目的 探讨HPV16、HPV18、HSV-2多重感染在宫颈癌发病及其进展中的作用。方法 选择120例宫颈癌标本及60例正常宫颈组织标本分别作为宫颈癌组及对照组，采用RT-PCR技术进行HPV16、HPV18、HSV-2检测，比较两组HPV16、HPV18、HSV-2感染情况，并分析宫颈癌HPV16、HPV18、HSV-2感染与肿瘤分化程度及肿瘤分期的关系。结果 宫颈癌组HPV16、HPV18、HSV-2单独感染及混合感染构成比高于对照组。HPV16、HPV18、HSV-2多重感染与宫颈癌FIGO分期及分化程度呈现相关关系。结论 HPV16、HPV18、HSV-2多重感染同宫颈癌发病具有相关性，可能是宫颈癌发病及进展的高危因素。 　　[关键词] 宫颈癌；HPV16，HPV 18，HSV-2；多重感染；肿瘤分期；肿瘤分化 　　[中图分类号] R737.33 [文献标识码] A [文章编号] 1673-9701（2011）26-08-02 　　 　　Study on Correlation between HPV16，HPV18，HSV-2 Multiple Infection and Cervical Cancer 　　LIU Haiqing 　　Zhoushan City Maternal and Child Health Hospital，Zhoushan 316000，China 　　 　　[Abstract] Objective To investigate the effect and mechanism of Human papilloma virus （HPV）16，HPV18， herpes simplex virus（HSV）-2 multiple infection in cervical cancer. Methods All 120 tissue samples of uterine cervix cancer and 60 tissue Samples of cervix uteri in normal women were selected as uterine cervix cancer group and control group. Expressive rate of HPV16， HPV18 and HSV-2 were detected with RT-PCR，infaction rate of HPV16， HPV18 and HSV-2 were compared between uterine cervix cancer group and control groups. Correlation of HPV16，HPV18，HSV-2 infection with stage and differentiation of cervical cancer were analyzed. Results Solitary and multiple infection rate of HPV16， HPV18 and HSV-2 was higher in uterine cervix cancer group than in control group，correlation test shown that multiple infection HPV16， HPV18， HSV-2 was correlative with FIGO stage and differentiation of uterine cervix cancer. Conclusion Multiple infection HPV16， HPV18， HSV-2 was correlative with uterine cervix cancer， that maybe was high risk factor of genesis and progression in uterine cervix cancer. 　　[Key words] Cervical cancer； HPV16，HPV18；HSV-2；Tumor stage；Differentiation 　　 　　宫颈癌是女性常见的恶性肿瘤之一，其发病率位居女性恶性肿瘤的第2位，近年来的研究结果显示[1]，宫颈癌的发病率呈现上升趋势，发病年龄年轻化，病死率不断上升[1]，仍是女性恶性肿瘤死亡的主要原因之一。病毒感染是宫颈癌发病高度相关的因素之一，HPV16、HPV18、HSV-2均是宫颈组织容易感染的病毒，本文就HPV16、HPV18及HSV-2多重感