TACE治疗原发性肝癌不同栓塞剂肝损伤分析.docVIP

TACE治疗原发性肝癌不同栓塞剂肝损伤分析 　　【摘要】 目的：探讨肝动脉化疗栓塞术（TACE）治疗原发性肝癌不同栓塞剂的肝损伤情况。方法：60例原发性肝癌患者，按随机数字表法分成两组，每组30例，海藻酸钠组接受国产海藻酸钠载药微球，碘化油组采用碘化油进行动脉化疗栓塞，比较两组患者的肝功能情况。结果：海藻酸钠-TACE及碘化油-TACE均会导致一定程度的肝损伤，碘化油组的间接胆红素（IBIL）较海藻酸钠组损伤更重（P0.05）。结论：海藻酸钠和碘化油作为TACE的栓塞剂，均会导致一定程度的肝损伤，总体较为安全。 　　【关键词】 肝动脉化疗栓塞术； 原发性肝癌； 海藻酸钠； 碘化油； 肝损伤 　　Analysis of Liver Function Damage of Primary Hepatic Carcinoma Treated by Transcatheter Arterial Chemoembolization with Different Embolic Agents/WANG Hai-lin，HUANG Wu-kui，Pahaerding Baikere，et al.//Medical Innovation of China，2017，14（06）：017-020 　　【Abstract】 Objective：To analyze the liver function damage of primary hepatic carcinoma treated by transcatheter arterial chemoembolization （TACE） with different embolic agents.Method：A total of 60 patients with primary liver cancer were divided into two groups according to random number table method，30 cases in each group，accepted domestic Kelp Micro Gelation carrier drug microsphere was Kelp Micro Gelation group， iodized oil arterial chemotherapy embolization respectively was iodized oil group.For iodized oil control，did evaluation of the liver function of two groups were compared.Result：Kelp Micro Gelation carrier drug microsphere-TACE and iodized oil-TACE could lead to a certain degree of liver damage，the IBIL damage of iodized oil was heavier than Kelp Micro Gelation carrier drug microsphere（P0.05）.Conclusion：Kelp Micro Gelation and iodized oil as embolic agents of TACE all could lead to a certain degree of liver damage，however，the overall safe. 　　【Key words】 Transcatheter arterial chemoembolization； Primary hepatic carcinoma； Kelp Micro Gelation； Iodinated oil； Liver function damage 　　First-author’s address：The Affiliated Tumor Hospital of Xinjiang Medical University，Urumqi 830011，China 　　doi：10.3969/j.issn.1674-4985.2017.06.005 　　原发性肝癌（Primary Hepatic Carcinoma，PHC）是较为常见的消化道肿瘤，中国的原发性肝癌最新年发病和死亡病例数均在全球平均的50%以上，分别居中国恶性肿瘤的第2、3位[1-2]。肝动脉化疗栓塞术（TACE）是目前被专家学者公认的中晚期肿瘤治疗手段，栓塞剂常用的是碘化油，其为公认的安全栓塞剂，目前临床使用的也有海藻酸钠、PVA颗粒、明胶海?d颗粒、