ERPR和CerbB2在甲状腺癌中表达及意义.docVIP

ERPR和CerbB2在甲状腺癌中表达及意义 　　【摘要】 目的 研究ER、PR、C-erbB-2在甲状腺癌组织中的表达情况，探讨它们的相互关系及临床意义。方法 用免疫组化的方法检测ER、PR、C-erbB-2在甲状腺癌、甲状腺腺瘤和甲状腺正常组织中的表达，分析它们在不同病变组织中的表达状况以及与甲状腺癌临床病理参数的关系。结果 甲状腺癌组织中ER、PR、C-erbB-2的阳性表达率（58.5%、71.7%、41.5%）明显高于甲状腺腺瘤（36.0%、38.0%、20.0%）和甲状腺正常组织（4.0%、8.0%、4.0%）（P0.05）。结论 甲状腺癌、甲状腺瘤、甲状腺正常组织中均可检测到ER、PR、C-erbB-2的阳性表达，以甲状腺癌最高，提示女性激素可能是诱发甲状腺癌发生的重要因素；ER、PR、C-erbB-2在乳头状癌阳性率远高于其它分型，提示乳头状癌可能是女性激素依赖性肿瘤；在甲状腺癌中，ER、PR与C-erbB-2的表达呈负相关。联合检测ER、PR、C-erbB-2为进一步了解甲状腺癌的发生发展，判断甲状腺癌的恶性程度、预后及有无淋巴结转移有重要意义。 　　【关键词】 ER； PR； C-erbB-2； 甲状腺癌； 免疫组织化学 　　Significance of The Expression of ER，PR，C-erbB-2 in thyroid carcinoma TIAN Meng-zi*/sup，BI Yan-qing*/sup，ZHAO Xiao-hua.*/supDongying Peoples Hospital，Dongying 257091 China 　　【Abstract】 Objective To study the expression of ER,PR andC-erbB-2 in thyroid carcinoma,to explore the relations among them and their clinical values.Methods Normal thyriod tissues,thyroid adenoma and thyroid carcinoma were evaluated for the expression of ER,PR and C-erbB-2 by immunohistochemistry,the levels of these proteins in tissues with different types of lesion and their correlation with clinicopathological parameters of thyroid carcinoma were analyzed.Results Compared with normal thyroid tissues and thyroid adenoma,the expression rates of ER,PR and C-erbB-2 of thyroid carcinoma increased obviously,there was significant difference between thyroid carcinoma and them（P0.05）.Conclusion The positive expression of ER,PR andC-erbB-2 were detected in normal thyroid tissues,thyroid adenoma and thyroid carcinoma.The expression in thyroid carcinioma was highest among them.Female sex hormone was probably a improtant agent induced the devolpment of thyroid carcinoma.It was close associated with the devolpment of thyroid carcinoma.The positive rates of ER,PR andC-erbB-2 in papillocarcinoma were higher than them in other thyroid carcinoma pathological types. Papillocarcinoma was probably a female sex hormone-dependent tumor.The expression of ER and PR were negative correlated wi