Syndecan1和乙酰肝素酶1在结直肠癌中表达及对其转移和预后影响.docVIP

Syndecan1和乙酰肝素酶1在结直肠癌中表达及对其转移和预后影响 　　[摘要] 目的 探讨Syndecan-1和乙酰肝素酶1（heparanase 1，HPA1）在结直肠癌组织中的表达水平和对其转移和预后的影响。 方法 采用原位杂交技术检测177例结直肠癌组织中Syndecan-1和HPA1的表达水平，比较Syndecan-1、HPA1 mRNA表达与结直肠癌临床病理指标、疾病预后的关系。 结果 在177例标本中，Syndecan-1 mRNA和HPA1 mRNA的阳性例数分别为75例和99例；Syndecan-1 mRNA及HPA1 mRNA阳性表达率与肿瘤浸润深度、TNM分期、淋巴结转移、远处转移和脉管癌栓密切相关（P0.01）；Syndecan-1 mRNA水平与HPA1 mRNA表达呈负相关（P0.01）；Syndecan-1 mRNA低表达平均生存时间和5年生存率低于高表达组，HPA1 mRNA阳性表达平均生存时间和5年生存率低于阴性表达组。 结论 Syndecan-1低表达和HPA1高表达对结直肠癌的侵袭和转移具有协同作用；两者结合有助于术后评估疗效和判断预后。 　　[关键词] Syndecan-1；乙酰肝素酶1；结直肠癌；预后 　　[中图分类号] R735.3[文献标识码] A[文章编号] 1674-4721（2014）04（c）-0015-03 　　 　　The impact of mRNA expression of syndecan-1 and heparanase1 in relation to tumor progression and prognosis of colorectal cancer 　　CHEN Yu-ning1 ZHANG Yi1 JIANG Fu-bing2 　　1.Department of Gastroenterology,the Third People′s Hospital of Huizhou City in Guangdong Province,Huizhou 516002,China;2.Department ofGastrointestinal Surgery,the Third People′s Hospital of Huizhou City in Guangdong Province,Huizhou 516002,China 　　[Abstract] Objective To investigate the mRNA expression of syndecan-1 and heparanase 1 in colorectal cancer，and their relationship between the progression and prognosis of the diseases. Methods In situ hybridization was used to examine mRNA expression of syndecan-l and HPA1 in 177 specimens of colorectal cancer.The relationship between mRNA expression and pathology indicators as well as prognosis of disease was observed. Results The positive numbers of syndecan-1 mRNA and HPA1 mRNA were 75 cases and 99 cases.The expression of syndecan-1 mRNA and HPA1 mRNA were related to tumor invasion depth,lymph node metastasis,TNM,distant metastasis and vessel invasion (P0.01).There was a negative relationship between Syndecan-1 mRNA and HPA1 mRNA expression (P0.01).The mean survival time of cases with low expression of syndecan-1 mRNA was significantly shorter than that of cases with high expression.The mean survival time of heparanase mRNA positive cases was significantly