TCTHPV和阴道镜下宫颈组织活检对宫颈病变诊断价值.docVIP

TCTHPV和阴道镜下宫颈组织活检对宫颈病变诊断价值 　　[摘要] 目的 探讨液基薄层细胞学技术（TCT）、人乳头状瘤病毒（HPV）检测与阴道镜下宫颈组织活检对宫颈病变的诊断意义。 方法 2013年12月～2015年8月我院门诊和体检5137人中335例TCT筛查异常患者进行HPV检测、阴道镜检查并取宫颈组织活检，以组织病理学为标准，比较3种方法对诊断宫颈病变的意义。 结果 ①宫颈组织活检阳性检出率明显高于TCT阳性、HPV阳性检出率（P0.01）。②HPV阳性组宫颈上皮内瘤样变的发病率显著高于阴性组（P0.01）；HPV阳性组宫颈病变程度亦明显高于阴性组（P0.05）。③随宫颈细胞学检查结果级别的增加，HPV感染的发生率升高，病理诊断为宫颈上皮内瘤变的数量亦增加（P0.05），TCT、HPV检测联合阴道镜下宫颈活检阳性率可达100.00%。 结论 TCT、HPV检测和阴道镜检查及活检是诊断宫颈病变重要的辅助措施，三者各有长短，适时综合运用可提高宫颈病变的检出率。 　　[关键词] 宫颈上皮内瘤变；液基薄层细胞学；人乳头瘤病毒；阴道镜；宫颈活检术 　　[中图分类号] R711.74 [文献标识码] A [文章编号] 1674-4721（2016）04（b）-0084-04 　　[Abstract] Objective To explore the diagnosis meaning of thinprep liquid-based cytology test（TCT），human papillomavirus（HPV）test and cervical biopsy under colposcope for cervical lesions. Methods TCT screening patients with abnormal，among 5137 people，from December 2013 to August 2015 of outpatient and physical examination in our hospital were tested with HPV test，colposcopy examination and cervical tissues were got for biopsy.The meaning of three methods for diagnosis cervical lesions was compared on the standard of histopathology. Results ①The positive detection rate of cervical biopsy was obvious higher than the positive detection rate of TCT and HPV（P0.01）.②The incidence of cervical intraepithelial neoplasia in HPV positive group was significantly higher than that in negative group（P0.01），and the degree of cervical lesions in HPV positive group was significantly higher than that in negative group（P0.05）.③With the increased of cervical cytological inspection results degree，the incidence rate of HPV infection increased and the number of pathological diagnosis as cervical intraepithelial neoplasia increased（P0.05）.The positive rate of TCT，HPV combined with cervical biopsy under colposcope was 100.00%. Conclusion TCT，HPV test and colposcopy examination and biopsy are assist measure for diagnosis cervical lesions.All of the three have advantages and disadvantages，and integrated use of them can increase the detection rate of cerv