不同血液净化方法对肾性骨病相关因子影响.docVIP

不同血液净化方法对肾性骨病相关因子的影响 　　【摘要】 目的：分析不同血液净化方法对肾性骨病相关因子的影响。方法：选取本院收治进行血液透析的肾性骨病患者326例并分为两组。对照组采用普通血液透析方式进行治疗；观察组采用联合式血液净化方式进行治疗。比较两组患者治疗前后各项指标的变化，同时计算钙磷乘积。结果：观察组临床治疗效果显著高于对照组，不良反应显著低于对照组（P0.05）。结论：采用联合式血液净化方式可以更好地清除患者体内甲状旁腺激素和β2-微球蛋白，并修复患者体内钙磷代谢紊乱的现象。 　　【关键词】 血液净化； 肾性骨病； 相关因子； 影响 　　【Abstract】 Objective：To analyze the effect on the related factors of renal osteopathy of different blood purification method.Method：From January 2009 to August 2014，a total of 326 patients with renal osteopathy treated in our hospital by blood dialysis were randomly divided into two groups.163 cases of patients in the control group were treated using common blood purification method； 163 cases of patients in the observation group were treated with combined-type blood purification methods.The blood blood calcium， phosphorus， parathyroid hormone，the change of the beta 2-microglobulin and the calcium-phosphorus product in the two groups before and after treatment were compared.Result：After treatment， blood calcium content of the patients in the observation group significantly increased（P0.05），and the blood phosphorus，parathyroid hormone，beta 2-microglobulin and calcium-phosphorus product significantly decreased（P0.05）.But all the indexes of patients of the control group changed non-significantly.Clinical therapeutic effect of the observation group was significantly higher than the control group， but the adverse reaction was significantly lower than that in the control group（P0.05）.Conclusion：The effects on the related factors of renal osteopathy of different blood purification methods are different.Combined-type blood purification methods can better remove patients parathyroid hormone and beta 2-macroglobulin，and repair the body calcium phosphorus metabolism disorder phenomenon. 　　【Key words】 Blood purification； Renal osteopathy； Relevant factors； Effect 　　当前，随着血液净化技术的不断发展和在临床上的广泛运用，其能够有效延长透析患者的生命，但与此同时，随着患者生命期的延长，患者中肾性骨病的发生率也在不断增长，这早已成为影响透析患者生命质量的最主要并发症之一[1]。肾性骨病，在临床上又可成为肾性骨营养不良，这种疾病与患者钙磷代