不同时期哮喘患者应用呼出一氧化氮测定临床意义.docVIP

不同时期哮喘患者应用呼出一氧化氮测定的临床意义 　　[摘要]目的 探讨不同时期哮喘患者应用呼出一氧化氮（FeNO）测定的临床意义。方法 选取2016年6～12月我院收治的30例哮喘患者作为哮喘组，另择同期于我院体检的30例非吸烟健康者作为对照组。比较两组治疗前（T1）、治疗4周（T2）、治疗12周时（T3）的FeNO检测值。结果 T1、T2及T3时，哮喘组患者的FeNO检测值均显著高于对照组，差异有统计学意义（P0.05）。T2时，哮喘组患者的FeNO检测值低于T1时，差异有统计学意义（P0.05）；T3时，哮喘组患者的FeNO检测值显著低于T1和T2时，差异有统计学意义（P0.05）。结论 不同时期哮喘患者的FeNO检测值均高于健康者，且随着治疗时间的增加，FeNO检测值逐渐降低，FeNO测定对哮喘的治疗有较好的指导作用。 　　[关键词]哮喘；呼出一氧化氮测定；诊断 　　[中图分类号] R563.9 [文献标识码] A [文章编号] 1674-4721（2018）1（b）-0041-03 　　[Abstract]Objective To investigate the clinical significance of fractional exhaled Nitric Oxide （FeNO） test in asthmatic patients at different stages.Methods 30 patients with asthma treated in our hospital from June to December 2016 were selected as asthma group of this study，and 30 non smokers in our hospital during the same period were selected as the control group.The FeNO values were compared between the two groups before treatment （T1），at 4 weeks （T2） and 12 weeks （T3） of treatment.Results At T1，T2 and T3，the FeNO values of patients in the asthma group were significantly higher than those in the control group，and the differences were statistically significant （P0.05）.At T2，the FeNO value of patients in the asthma group was lower than T1，and the difference was statistically significant （P0.05）.At T3，the FeNO value of patients in the asthma group was significantly lower than that of T1 and T2，and the differences were statistically significant （P0.05）.Conclusion The FeNO value of patients in the asthma group at different stages are higher than those of healthy people，and with the increase of treatment time，the detection value of FeNO gradually decreased，and the FeNO test has a good guiding role in the treatment of asthma. 　　[Key words]Asthma；Fractional exhaled Nitric Oxide test；Diagnosis 　　支?夤芟?喘（简称哮喘）的发病原因是变应原或其他因素造成支气管出现广泛的可逆性气道狭窄性疾病，研究表明，哮喘是由多细胞或细胞组参与的一种慢性气道炎症性疾病[1]，因此导致哮喘的主要原因是机体炎症反应。多数研究表明，依据哮喘患者炎症检测结果给予针对性治疗可显著改善患者的症状[2]。但目前临床中大多数炎症检测方法主要是是肺泡灌洗技术、诱导痰检查及支气管镜检等方式，大多数都是通过对气管细胞或中介物完成检测，这种方式一般成本高，操作复杂，存在侵入性，对患者