二甲双胍对新诊断2型糖尿病患者血清促甲状腺激素水平影响.docVIP

二甲双胍对新诊断2型糖尿病患者血清促甲状腺激素水平的影响 　　[摘要] 目的 ?^察二甲双胍对新诊断2型糖尿病（T2DM）合并甲状腺功能减退症患者血清促甲状腺激素（TSH）水平的影响。 方法 选取病程1～3年的2型糖尿病合并原发性甲状腺功能减退症、亚临床甲状腺功能减退症患者，按是否服用左甲状腺素片分为两组：1组：服用二甲双胍且给予左甲状腺素治疗糖尿病组（48例）；2组：服用二甲双胍但未予左甲状腺素平治疗糖尿病组（39例）。另外设立组3为对照组：服用二甲双胍但甲状腺功能正常糖尿病患者（35例）。测定各组患者不同时间血清FT3、FT4、TSH，各时间空腹血糖、糖化血红蛋白、体重指数等指标变化。 结果 治疗24周后：1组TSH水平由治疗前的（6.85±1.02）uIU/mL降低至（2.34±0.81）uIU/mL（P0.05）。三组患者治疗的空腹血糖、糖化血红蛋白较前均有所下降（P0.05）。 结论 服用二甲双胍可降低糖尿病患者血清促甲状腺激素水平，有效改善新发2型糖尿病糖尿病患者血糖水平。 　　[关键词] 甲状腺功能减退症；二甲双胍；促甲状腺素；2型糖尿病 　　[中图分类号] R587.1 [文献标识码] B [文章编号] 1673-9701（2017）29-0000-03 　　Effect of metformin on serum thyrotropin in newly diagnosed type 2 diabetic patients 　　GAO Yanchao WANG Yan 　　Department of Endocrinology， the Second Hospital of Chaoyang City in Liaoning Province， Chaoyang 122000， China 　　[Abstract] Objective To observe the effect of metformin on serum thyrotropin（TSH） in newly diagnosed type 2 diabetes mellitus（T2DM） with hypothyroidism. Methods Patients with type 2 diabetes mellitus complicated with primary hypothyroidism and subclinical hypothyroidism whose course was 1 to 3 years were divided into two groups according to whether or not levothyroxine tablets were taken. The group 1（n=48） was treated with metformin and levothyroxine and the group 2 （n=39） was given metformin but not levothyroxine. In addition， group 3 was established as the control group （n=35）， and the patients who had normal thyroid function were taken metformin. The levels of serum FT3， FT4， TSH， and the changes of indicators including fasting blood glucose， glycosylated hemoglobin and body mass index in each group at different time were measured. Results After 24 weeks of treatment， the TSH level in group 1 was decreased from （6.85±1.02） uIU/mL before treatment to （2.34±0.81） uIU/mL（P0.05）. The levels of fasting blood glucose and glycosylated hemoglobin in all the three groups after treatment were decreased compared with those before treatment（P0.05）. Conclusion Taking metformin can reduce the serum thyrotropin leve