临床药学监测在头孢哌酮舒巴坦治疗呼吸道感染多重耐药革兰阴性菌中应用.docVIP

临床药学监测在头孢哌酮舒巴坦治疗呼吸道感染多重耐药革兰阴性菌中的应用 　　[摘要] 目的 探?临床药学监测在头孢哌酮/舒巴坦治疗呼吸道感染多重耐药革兰阴性菌中的应用。 方法 收集2016年1 ～ 12月期间我院病原学送检标本5880个，所有标本均进行痰液病原菌培养，采用K-B纸片扩散法测定头孢哌酮/舒巴坦对多重耐药革兰阴性菌的抗菌活性，统计分析所有标本病原菌感染及其耐药性情况。 结果 本次研究中，共检出革兰阴性菌植株1100株（18.71%），其主要以铜绿假单胞菌263株（4.47%）、肺炎克雷伯菌254株（4.32%）、大肠埃希菌189株（3.21%）为主，多重耐药菌186株（3.16%），其主要以大肠埃希菌62株（1.05%）、鲍曼不动杆菌46株（0.78%）、肺炎克雷伯菌254株（0.48%）为主；抗菌活性分析结果显示，头孢哌酮/舒巴坦对多重耐药革兰阴性菌抗菌活性最高的三种细菌分别为大肠埃希菌93.55%、铜绿假单胞菌85.71%、肺炎克雷伯菌82.14%。 结论 铜绿假单胞菌、肺炎克雷伯菌、大肠埃希菌是本次呼吸道感染主要的革兰阴性菌感染菌，其中大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌是该疾病主要的多重耐药菌，头孢哌酮/舒巴坦对多重耐药菌的抗菌活性存在差异，应针对病原菌合理性使用。 　　[关键词] 监测；头孢哌酮/舒巴坦；呼吸道感染；多重耐药；革兰阴性菌 　　[中图分类号] R97 [文献标识码] A [文章编号] 2095-0616（2017）11-68-03 　　Application of clinical pharmacy monitoring in cefoperazone/sulbactam in treatment of multi-drug resistance gram-negative bacteria of respiratory tract infection 　　TAN Sen 　　Clinical Pharmaceutics Room，Wuchuan Peoples Hospital，Wuchuan 524500，China 　　[Abstract] Objective To explore application of clinical pharmacy monitoring in cefoperazone/sulbactam in treatment of multi-drug resistance gram-negative bacteria of respiratory tract infection. Methods 5880 etiology examined samples in our hospital from January 2016 to December 2016 were collected and all samples were given sputum pathogen culture.Antibacterial activity of cefoperazone/sulbactam in multi-drug resistance gram-negative bacteria was detected by Kirby-Bauer disc diffusion method.Pathogens infection and drug resistance of all samples were statistically analyzed. Results In this study，a total of 1100 strains of gram-negative bacteria plants were detected（18.71%） and they mainly included 263 strains of pseudomonas aeruginosa（4.47%），254 strains of Klebsiella pneumonia（4.32%） and 189 strains of escherichia coli（3.21%）.In addition，186 strains of multi-drug resistant bacteria were also detected.Of which，there were mainly 62 strains of escherichia coli（1.05%），46 strains of acinetobacter baumannii （0.78%） and 254 strains of Klebsiella pneumonia（0.48%）.Analysis results of ant