乙型肝炎患者血清免疫球蛋白水平变化及其临床意义.docVIP

乙型肝炎患者血清免疫球蛋白水平的变化及其临床意义 　　[摘要] 目的 分析研究乙型肝炎患者血清免疫球蛋白水平的变化及其临床意义。方法 随机选取该院从2013年8月―2014年6月收治的住院60例乙型肝炎患者，根据患者的病情划分为一般组、重症组，并选取同期健康献血的40名正常人为对照组，根据免疫比浊法测定受检者的血清免疫球蛋白水平。结果 一般组、重症组患者的免疫球蛋白水平与对照组相比，差异有统计学意义（P0.05），且一般组、重症组的免疫球蛋白水平比较，差异有统计学意义（P0.05）；两组患者用药治疗后有效控制病情，重型组、一般组患者的免疫球蛋白水平与治疗前相比有明显下降，但与正常组相比，差异有统计学意义（P0.05）。 结论 乙型肝炎患者的血清免疫球蛋白水平可直接反应患者的肝功能，为之后乙肝诊断、治疗以及预后提供可参考的依据。 　　[关键词] 乙肝肝炎；血清免疫球蛋白；临床意义 　　[中图分类号] R59 [文献标识码] A [文章编号] 1674-0742（2015）08（b）-0020-02 　　[Abstract] Objective To Analyze the changes of serum immunoglobulin levels for hepatitis B patients and its clinical significance. Methods 60 cases of patients with hepatitis B， accepted in our hospital from August 2013 to June 2014， were selected， and were divided into general group and severe group， according to their condition， and 40 normal healthy blood donors in the same period， were selected as control group. Subjects’ serum immunoglobulin levels were determined by immunonephelometry. Results The general group and severe group compared with the control group， the difference of the immunoglobulin levels was significant， and P0.05 was statistically significant. Two groups of patients’ disease were effectively controlled with medication treatment， and the immunoglobulin levels of severe group and general group were significantly decreased， compared with that of before treatment， but compared with that of the normal group， there was still significant difference， P0.05 was statistically significant. Conclusion Serum immunoglobulin level of patients with hepatitis B， can directly reflect the liver function of patients， and can provide a reference basis for later diagnosis， treatment and prognosis of hepatitis B. 　　[Key words] Hepatitis B； Serum immunoglobulin； Clinical significance 　　乙型病毒性肝炎为一种常见传染性疾病，为一种具有较高传染性疾病，病情难以彻底治愈，容易反复发作，危险性高，因此治疗的重点在于控制传染性以及危害性。该疾病发病机理比较复杂，该疾病的发生率、传染率高，若未治疗，可能会恶化为肝癌或肝硬化，因此做好患者病情的监测，对于提高临床预后，十分重要[1]。免疫球蛋白类似于抗体，有抗体活性，可特异性与抗原结合，发挥免疫效应。在人体血清中，免疫球蛋白主各个指标的特点以及分工不同，对于早期评价机体免疫情况效果显著。该研究随机选取该