介入治疗对肝门部胆管癌患者效果及甲胎蛋白γ―谷氨酰转肽酶水平影响.docVIP

介入治疗对肝门部胆管癌患者的效果及甲胎蛋白、γ―谷氨酰转肽酶水平的影响 　　【摘要】 目的：探?介入治疗对肝门部胆管癌患者的效果及甲胎蛋白、γ-谷氨酰转肽酶水平的影响。方法：选取2009年6月-2013年6月在本院诊断为肝门部胆管癌的患者89例，根据治疗方法不同分为研究组（n=44）和对照组（n=45），研究组采用介入治疗，对照组采用外科手术切除治疗。观察两组患者术后甲胎蛋白（alpha fetoprotein，AFP）及γ-谷氨酰转肽酶（γ-glutamyl transpeptidase，γ-GT）水平、住院时间，随访并记录患者术后3年生存率。结果：治疗后，两组患者的γ-GT水平均明显低于治疗前，且研究组低于对照组，差异均有统计学意义（P0.05）；研究组患者的住院时间显著短于对照组，差异有统计学意义（P0.05）。结论：肝门部胆管癌患者采用介入治疗的方式有缩短住院时间、恢复快的优点，且可以改善肝功能。 　　【关键词】 介入治疗； 肝门部胆管癌； 甲胎蛋白； γ-谷氨酰转肽酶； 3年生存率 　　Effect of Interventional Therapy on Hilar Cholangiocarcinoma and Its Effect on Alpha Fetoprotein，γ-glutamyl Transpeptidase/SHEN Bo，LUO Jun-feng，PAN Jing-gang，et al.//Medical Innovation of China，2017，14（30）：103-106 　　【Abstract】 Objective：To investigate the effect of interventional therapy in patients with hilar cholangiocarcinoma and alpha fetoprotein，γ-glutamyl transpeptidase levels.Method：89 patients with hilar cholangiocarcinoma diagnosed in our hospital from June 2009 to June 2013 were divided into the study group（n=44） and the control group（n=45） according to different treatment methods.The study group was treated with interventional therapy，the control group was treated with surgical resection.Alpha fetoprotein（AFP） and γ-glutamyl transpeptidase（γ-GT） levels，hospitalization time were observed，follow-up and recorded the 3-year survival rate of the patients after operation.Result：After treatment，the level of γ-GT in the two groups were significantly lower than those before treatment，and the study group was lower than that of the control group，the differences were statistically significant（P0.05）；the hospitalization time in the study group was significantly shorter than that of the control group，the difference was statistically significant（P0.05）.Conclusion：The interventional therapy for hilar cholangiocarcinoma has the advantages of shorter hospitalization time and quicker recovery， and can improve the liver function. 　　【Key words】 Interventional therapy； Hilar cholangiocarcinoma； Alpha fetoprotein； γ-glutamyl