聚l乳酸2f大豆分离蛋白2f二氧化锆纳米纤维膜的制备及性能研究.pdfVIP

ABSTRACT Electrospinning technique was used to fabricate the poly (L-lactic acid) complex fibers, including chloramphenicol (CP)-poly (L-lactic acid)/ zirconium dioxide (ZrO ) and Nisin -poly (L-lactic acid)/soybean protein isolated 2 (SPI)/zirconium dioxide nanofibrous membranes. In this paper, the influence of different electrospinning parameter and ratio of each component on the nanofibers structure, degradability, antimicrobial activity and drug release ability were characterized. Electrospinning technique was used to fabricate chloroamphenicol loaded poly (L-lactic acid)/ZrO (CP-PLLA/ZrO ) nanofibrous membranes. The 2 2 morphologies of the nanofibers were investigated by electron microscopy (SEM). When tio-to-collectotor distance (TCD) was 10 cm, voltage was 18 kV, the content of ZrO2 was 2% and the CP content was 8% , the microscopy of nanofibers was better. The results of Fourier infrared spectroscopy (FTIR), scanning photoelectron spectroscopy (XPS) and thermogravimetric analysis (TG) showed that the existence of hydrogen and Zr–O–C bonds between PLLA and ZrO2 units improved the thermal stability of PLLA. The CP-PLLA/ZrO2 nanofibrous membranes revealed better antimicrobial activity against S. aureus. and well controlled release. Electrospinning technique was used to fabricate Nisin -poly (L-lactic acid)/soybean protein isolated (SPI)/