卡前列素氨丁三醇注射液预防高危剖宫产产后出血临床疗效及安全性评价.docVIP

卡前列素氨丁三醇注射液预防高危剖宫产产后出血临床疗效及安全性评价 　　[摘要] 目的 探讨卡前列素氨丁三醇注射液（欣母沛）预防高危剖宫产后出血的临床疗效及安全性。 方法 选择2013年1月～2014年1月期间我院收治的有产后出血倾向的剖宫产产妇104例，根据随机数表法将其平均分为研究组与对照组各52例。两组产妇均行剖宫产手术，胎儿娩出后静滴20 U缩宫素，在此基础上对照组舌下含服米索前列醇，研究组肌注欣母沛。观察两组产后出血发生情况。 结果 研究组产后2 h及产后24 h出血量显著低于对照组（P0.05）。 结论 欣母沛是预防高危剖宫产后出血的有效方法，可以显著降低产后出血的发生率，安全性好，适于临床应用。 　　[关键词] 欣母沛；高危；剖宫产；产后出血 　　[中图分类号] R719.8 [文献标识码] B [文章编号] 1673-9701（2015）20-0038-03 　　Clinical efficacy and safety of carboprost tromethamine injection on preventing high-risk postpartum hemorrhage of cesarean section 　　ZHOU Bin WANG Chuanhong CHEN Jingge CHE Yanhong 　　Department of Obstetrics and Gynecology， Zhengzhou City MCH， Zhengzhou 450000，China 　　[Abstract] Objective To investigate the efficacy and safety of carboprost tromethamine injection（hemabate） on preventing high-risk postpartum hemorrhage of cesarean section. Methods 104 cases of high-risk postpartum hemorrhage of cesarean section from 2013 January to 2014 January in our hospital were selected， which were randomly divided into study group and control group， 52 cases in each group. Two groups of parturients underwent cesarean operation， after delivery of fetus 20 U intravenous drip of oxytocin， on the basis of this group of sublingual misoprostol， the study group was injected hemabate. Then the occurrence of postpartum hemorrhage of the two groups were observed. Results The amount of 2 h and 24 h bleeding postpartum postpartum of the study group were significantly lower than those of the control group（P0.05）. Conclusion Hemabate is a effective method to prevent the risk of postpartum hemorrhage of cesarean section， it can significantly reduce the incidence of postpartum hemorrhage， has higher safety， and is suitable for clinical application. 　　[Key word] Hemabate； High-risk； Cesarean section； Postpartum hemorrhage 　　产后出血是产科常见且多发的并发症之一，是指胎儿娩出血的24 h内，产妇出血量超过500 mL[1]。有资料统计，约有2%～3%的产妇分娩后可发生产后出血，该并发症在我国产妇死亡原因中高居首位[2]。造成产后出血的常见原因有胎盘因素、子宫收缩乏力、软产道损伤及弥散性血管内凝血（dessiminated intiavascular coagulation，