右美托咪定对舒芬太尼术后静脉镇痛患者恶心呕吐影响.docVIP

右美托咪定对舒芬太尼术后静脉镇痛患者恶心呕吐影响 　　[摘要] 目的 ?^察右美托咪定（DEX）对舒芬太尼术后静脉镇痛患者恶心呕吐（PONV）的影响。 方法 选择2015年1月～2016年6月于武警四川省总队医院择期行后路脊柱融合术患者100例，采用随机数字表法分为舒芬太尼组（S组）和DEX复合舒芬太尼组（SD组），每组各50例。SD组患者术毕前30 min静脉注射DEX 0.5 μg/kg，术后静脉镇痛为DEX 2 μg/kg+舒芬太尼 2 μg/kg。S组术毕前30 min给予生理盐水，术后静脉镇痛为舒芬太尼2 μg/kg。记录两组PONV发生率和严重程度、术后48 h内追加舒芬太尼总量、甲氧氯普胺用量及疼痛评分。 结果 术后1～3 h SD组患者PONV发生率显著低于S组（P 1～3、3～6 h和6～12 h SD组发生中重度PONV患者比例显著低于S组（P 0.05）。 结论 DEX对舒芬太尼术后静脉镇痛引起的PONV有预防作用。 　　[关键词] 右美托咪定；舒芬太尼；术后镇痛；术后恶心呕吐 　　[中图分类号] R614.2 [文献标识码] A [文章编号] 1673-7210（2017）05（a）-0078-04 　　Effect of Dexmedetomidine on preventing nausea and vomiting in patients with Sufentanil for postoperative intravenous analgesia 　　SUN Fuguo1 JIN Liang2 HE Qinwei1 ZHENG Peng1 　　1.Department of Anesthesiology， Chinese Peoples Armed Police Corps Hospital in Sichuan Province， Leshan 614000， China； 2.Department of Anesthesiology， Leshan Peoples Hospital， Sichuan Province， Leshan 614000， China 　　[Abstract] Objective To study the effect of Dexmedetomidine on preventing nausea and vomiting （PONV） in patients with Sufentanil for postoperative intravenous analgesia. Methods 100 patients underwent posterior lumbar spinal fusion in Chinese Peoples Armed Police Corps Hospital in Sichuan Province from January 2015 to June 2016 were recruited. All patients were allocated into group Sufentanil （group S） and group Sufentanil-Dexmedetomidine （group SD） by random number table， each group had 50 cases. Patients in group SD received Dexmedetomidine 0.5 μg/kg intravenously 30 min before the completion of surgery， and Sufentanil 2 μg/kg plus Dexmedetomidine 2 μg/kg made up to a total volume of 100 mL for postoperative intravenous analgesia. Normal saline was injected 30 min before the end of surgery， and then Sufentanil 2 μg/kg was made up to a total volume of 100 mL for analgesia in group S. The incidence and severity of PONV， cumulative dose of Sufentanil for rescue analgesia and Metoclopramide in the first 48 h after surgery were recorded. Pain scores were assesse