奈达铂联合多西他赛治疗局部晚期宫颈癌疗效观察.docVIP

奈达铂联合多西他赛治疗局部晚期宫颈癌疗效观察 　　[摘要] 目的 对奈达铂联合多西他赛治疗局部晚期宫颈癌的疗效进行评价。 方法 选择的研究对象为2014年1月～2015年1月入住我院的局部晚期宫颈癌患者100例， 根据治疗方法不同随机分为观察组及对照组，每组各50例。对照组予多西他赛70 mg/m2静滴，第1天，每周1次，化疗21 d为1个周期；观察组联合奈达铂70 mg/m2，第1天，化疗21 d为1个周期。所有患者均行2个周期化疗。对两组治疗后的疗效及毒副反应进行对比分析。 结果 治疗2个周期后，观察组完全缓解24例，部分缓解16例，稳定8例，进展2例；对照组完全缓解18例，部分缓解12例，稳定14例，进展6例，两组有效率组间比较，差异有统计学意义（80.00% vs 60.00%，P0.05）。两组的毒副反应主要以恶心、呕吐等消化道反应、骨髓抑制为主，骨髓抑制主要为白细胞下降，予重组人粒细胞刺激因子治疗后恢复正常，部分患者出现血小板减少，予重组人粒细胞刺激因子治疗后均恢复正常。消化道反应主要表现为恶心呕吐、食欲降低、腹泻等，但多为Ⅰ或Ⅱ度，化疗结束后即明显缓解。观察组消化道反应的发生率、骨髓抑制的发生率分别显著低于对照组，差异具有统计学意义（P0.05）。 结论 奈达铂联合多西他赛治疗局部晚期宫颈癌疗效确切，且毒副反应少，安全性好，值得推广和应用。 　　[关键词] 局部晚期宫颈癌；奈达铂；多西他赛；毒副反应 　　[中图分类号] R737.33 [文献标识码] B [文章编号] 1673-9701（2015）29-0082-04 　　The efficacy of nedaplatin combined with docetaxel in treatment of locally advanced cervical cancer 　　LIN Aidi KE Xiaohui HUANG Yitong 　　Department of Gynecology， Wenzhou City Center Hospital in Zhejiang Province， Wenzhou 325000， China 　　[Abstract] Objective To evaluate the efficacy of nedaplatin combined with docetaxel in treatment of locally advanced cervical cancer. Methods From January 2014 to January 2015， 100 cases patients with locally advanced cervical cancer according to the treatment method were randomly divided into observation group and control group， each group with 50 cases， patients in control group were treated with docetaxel 70 mg/m2 intravenously， the first day， 1 week chemotherapy for 21 days a cycle， the observation group combined with nedaplatin 70 mg/m2， on the first day of chemotherapy for 21 days a cycle. All patients underwent 2 cycles of chemotherapy. The efficacy and toxicity of the two groups were compared and analyzed. Results After 2 cycles of treatment， the observation group 24 cases of complete remission， partial remission in 16 cases， 8 cases were stable， progress in 2 cases， control group completed remission in 18 cases， partial remission in 12 cases， stable in 14 cases， progress in 6 cases， the difference was significant between two groups （80.00% vs 60.00%