妊娠晚期HPV潜伏感染对妊娠结局影响探讨.docVIP

妊娠晚期HPV潜伏感染对妊娠结局影响探讨 　　【摘要】 目的：探讨妊娠晚期HPV潜伏感染对妊娠结局的影响情况。方法：选取2008年2月-2014年4月本院妊娠晚期HPV潜伏感染产妇46例作为观察组，选取同期正常孕妇50例作为对照组。观察两组研究对象阴道pH值、阴道菌群情况及妊娠结局情况。结果：两组阴道pH值和细菌性阴道炎比较差异均有统计学意义（ 字2=6.89、12.17，P0.05）；观察组胎膜早破、产褥感染、胎儿窘迫、产后出血发生率均高于对照组，差异均有统计学意义（ 字2=6.56、4.39、9.09、6.72，P0.05）。结论：妊娠晚期HPV潜伏感染可能对妊娠结局造成不良影响，应进行有效治疗。 　　【关键词】 妊娠晚期； HPV潜伏感染； 妊娠结局； 影响 　　The Pregnancy Outcomes Influence of Late Pregnancy Combined with Latent Infection of HPV/JIA Yan-hong.//Medical Innovation of China，2015，12（15）：097-100 　　【Abstract】 Objective：To discuss pregnancy outcomes influence of in late pregnancy combined with latent infection of HPV.Method：46 cases who in late pregnancy combined with latent infection of HPV were selected as the observation group in our hospital from February 2008 to April 2014，which 50 cases of pregnant woman were selected as the control group.The situation that the research object of the both groups who vaginal pH and vaginal flora，and observe the situation that pregnancy outcomes of the both groups were observed.Result：The difference of vaginal pH and bacterial vaginosis in the two groups had statistical significance（ 字2= 6.89， 12.17，P0.05）.The premature rupture of membranes， puerperal infection， fetal distress， the incidence of postpartum hemorrhage of the observation group were higher than the control group，the differences were statistical significance （ 字2=6.56， 4.39， 9.09， 6.72，P0.05）.Conclusion：Pregnancy late HPV latent infections could cause adverse influence on pregnancy outcome， which should give effective treatment. 　　【Key words】 In late pregnancy； Latent infection of HPV； Pregnancy outcomes； Influence 　　First-author’s address：The Maternal and Child Care Service Centre of Baoan in Shenzhen City，Shenzhen 518000，China 　　doi：10.3969/j.issn.1674-4985.2015.15.033 　　人乳头瘤装病毒（HPV）是育龄妇女常见的生殖系统感染病毒，其主要通过性传播，容易诱发生殖系统的尖锐湿疣等疾病，严重者可能导致宫颈癌、肛门癌等恶性肿瘤[1-2]。近年来随着人们生活方式的变化，HPV感染发生率呈现明显增高的趋势。HPV的DNA可以和人体DNA在表皮细胞层进行复制并且整合到人体细胞中，向细胞核侵入，诱发细胞核发生分裂，从而诱导上皮细胞增殖，对细胞原有的生长调控造成破坏，诱发棘细胞增生、