VEGF-A和MVD在大肠癌中的表达及预后意义-临床医学专业论文.docxVIP

遵义医学院硕士学位论文骆礼波 遵义医学院硕士学位论文 骆礼波 万方数据 万方数据 VEGF-A 和 MVD 在大肠癌中的表达及预后意义 中文摘要 目的：探讨血管内皮生长因子 A（Vascular Endothelial Growth Factor-A VEGF-A)和 微血管密度（Microvessel Density MVD)在大肠癌组织中的表达与患者生存预后关 系。 方法：收集近 10 年间收治生存期≥5 年及≤3 年大肠癌患者标本各 30 例，应用免疫组 织化学（Envision）测定这 60 例大肠癌组织中 VEGF-A 和 MVD 表达，分析检测结果 与临床病理特点及患者预后关系。 结果：≥5 年 30 例大肠癌患者 VEGF-A ,MVD 表达强度与≤3 年 30 例大肠癌患者在浸 润深度，TNM 分期，淋巴结转移间比较，均有显著性差异(p0.001)，而性别，年龄， 分化程度及病理分型差异性不显著（P0.050),且 VEGF-A 与 MVD 表达两者呈正相关 （r= 0.974 p0.05）。 结论：VEGF-A 对大肠癌的生长和浸润转移有促进作用，VEGF-A 和 MVD 可以作为 判断大肠癌患者预后重要参考指标。 关键词：大肠癌 ；VEGF-A； MVD； 预后 课题来源：遵医附院中青年科研启动基金院字（2010）05 号 课题主持者：程家平副教授 2 Expressions of VEGF-A,MVD in colorectal carcinoma and its prognostic significance Abstract Objective: To explore the expression of vascular Endothelial Growth Factor-A(VEGF-A) and Microvessel Density(MVD) in colorectal carcinoma and their prognostic significance. Methods : The colorectal cancer specimens from the patients who had been operated in our hospital over a past 10-year period were collected,with 30 cases of either survival time5 years or 3 years.Immunohistochemical technique (Envision) was used to detect the expression of VEGF-A and MVD in the 60 cases of colorectal carcinoma,The relationship of their expression with clinico-pathological features and prognosis of colorectal carcinoma was analyzed. Results: 5 years or 30 cases of patients with colorectal cancer VEGF-A and MVD expression strength and 3 years or less 30 cases in patients with colorectal cancer invasion depth of embellish, TNM stage, lymph node metastasis is compared between, all have significant difference (p 0.001), and gender, age, degree of differentiation and pathological parting differences are not significant (p 0.050), and VEGF-A and MVD expression positive correlation between both (r = 0.974 p 0.05). Conclusion: VEGF-A promotes growth ,invasion and metastasis of colorectal carcinoma.VEGF-A expression or MVD may be one of the important predictors for the prognostic marker of