UGT1A1基因Gly71Arg突变对新生儿高胆红素血症的影响儿科学专业论文.docxVIP

PAGE PAGE IV The UGT1A1 Gly71Arg mutation is associated with neonatal hyperbilirubinemia in Chinese populations. A/G、A/A genotype of Gly71Arg are the susceptible gene in neonatal hyperbilirubinemia, the Gly71Arg A allele is a risk factor of neonatal hyperbilirubinemia. Key words Neonatal; hyperbilirubinemia; UDP-glucuronosyltransferase 1A1; Genic mutation 缩写词中英文对照 英文缩写 英文全名 中文译名 UGT1A1 uridine diphosphate-glucuronosyltransferase 1A1 尿苷二磷酸葡萄糖醛酸转 移酶 1A1 G-6-PD glucose-6-phosphate dehydrogenase 葡萄糖-6-磷酸脱氢酶 OATP2 organic anion transporting polypeptide 2 有机阴离子转移多肽 2 GS Gilbert’s syndrome 吉尔伯特综合征 CN Crigler-Najjar syndrome 克里格勒-纳贾尔综合征 GSH glutathione 谷胱甘肽 CO carbon monoxide 一氧化碳 MRP2 multidrug-resistance protein 2 多药耐药相关蛋白 2 COHbc carboxy haemoglobin concentration 碳氧血红蛋白浓度 T3 triiodothyronine 三碘甲状腺原氨酸 PCR polymerase chain reaction 聚合酶链反应 bp base pair 碱基对 目 录 中文摘要························································Ⅰ 英文摘要························································Ⅱ 英文缩写表······················································Ⅳ 目录······························································Ⅴ 前言···························································· (1) 材料与方法······················································(6) 结果····························································(12) 讨论····························································(15) 结论····························································(21) 参考文献·······················································(22) 综述····························································(27) 致谢····························································(34) 发表论文·······················································(35) 个人简介·······················································.(36) PAGE PAGE 1 前 言 新生儿高胆红素血症是新生儿期常见的临床症状，约 60%新生儿在新生儿期可出现 不同程度黄疸。胆红素是一种内源性化合物，有毒副作用[1]。在新生儿期未结合胆红素对 脑组织的毒副作用尤为显著，