流化工艺对益母草提取物粉体学性质影响お.docVIP

流化工艺对益母草提取物粉体学性质影响お 　　[摘要]采用不同的黏合剂对益母草提取物进行流化改造，使用粉体学方法对改造前后益母草提取物的吸湿性、流动性、填充性等物性指标比较分析，研究直压辅料与改造后益母草提取物在粉末可压性与成型性上的差异，结果表明，益母草提取物各物性指标接近微晶纤维素，综合流动性指数分布在61～75；流化工艺可以改善其吸湿性，样品各吸湿指标都明显低于原益母草提取物；以塑性常数、压缩比与屈服应力、Heckel方程与川北方程为指标考察可压性，发现水作黏合剂对增强益母草提取物的可压性效果优于其他方法；在中低压力下流化改性物可以成型为有一定强度的片剂，通过对益母草提取物的流化研究，发现流化改造对原益母草提取物各种性质影响较大，结果可以为中药提取物的片剂开发提供基础理论依据。 　　[关键词]益母草提取物； 流化； 吸湿性； 可压性 　　Effect of fluidized bed technology on micromeritics properties of 　　Leonurus Herba extract 　　DU Yan1*， YI Qizhi2， XIONG Yaokun3， XU Lanping1 　　（1 College of Chemistry and Chemical Engineering， Jiangxi Normal University， Nanchang 330022， China； 　　2 College of Mathematics Information Science， Jiangxi Normal University， Nanchang 330022， China； 　　3 Key Laboratory for Modern Preparation of Traditional Chinese Medicine Under Ministry of Education， 　　Jiangxi University of Traditional Chinese Medicine， Nanchang 330011， China） 　　[Abstract]Based on different binders， the Leonurus Herba extract powders were fluidized and modified The physical properties such as hygroscopicity， flowability， filling property and compression property were studied by various micromeritics methods before and after modification The results showed that the physical properties of Leonurus Herba extract were close to those of microcrystalline cellulose， and its comprehensive flow index was between 6175 Fluidization process can improve hygroscopicity， so the moisture absorption indexes of the samples were significantly lower than those of the original Leonurus Herba extract samples With the plastic constant， compression ratio and yield stress， Heckel equation and Kawakita equation as the the investigation indicators， results showed that fluidization process based on binder water was superior to other methods in increasing the compressibility of the extracts In low and medium pressure， the fluidized and modified extract can form the tablets with a certain strength Fluidized transformation had a greater influence on the prop