尿毒症患者铁代谢相关指标检测研究进展.docVIP

尿毒症患者铁代谢相关指标检测研究进展 　　[摘要]慢性肾功能衰竭晚期即是尿毒症，尿毒症的主要实验室检测常规指标如尿素氮、肌酐等往往仅能够反映患者目前疾病的进展程度与透析效果，而尿毒症患者常常伴有由于铁代谢异常而导致的贫血，严重贫血时会大大影响患者的生活质量乃至患者的远期生存期，所以尿毒症患者常常需要进行一些铁代谢相关指标的检测，以指导临床医师及时补铁来纠正贫血，改善患者生存质量。目前常规的铁代谢相关指标主要有血清铁、总铁结合力、血清铁蛋白等。近年来，一种新的铁调节蛋白指标铁调素（Hepcidin）被发现。随后，越来越多的研究表明，铁调素是尿毒症血液透析患者铁代谢水平的重要平衡因素。本文主要从实验室检测的角度，在回顾尿毒症疾病的基本理论以及常用实验室检测指标的同时，探讨尿毒症患者铁代谢相关指标及铁调素在其中的重要作用。 　　[关键词]尿毒症；铁代谢；指标 　　[中图分类号] R446.1 [文献标识码] A [文章编号] 1674-4721（2016）07（b）-0015-03 　　[Abstract]The late stage of chronic renal failure is uremia，the main laboratory tests of uremia such as urea nitrogen，creatinine are often only able to reflect the degree of disease progression and dialysis effect.Uremic patients are often accompanied by anemia caused by abnormal iron metabolism and severe anemia will greatly affect the quality of life of patients and even the long-term survival of patients，so uremic patients often need to carry out some of the detection of iron metabolism related indicators to guide clinicians to make up iron in time in order to correct anemia and improve the quality of life of patients.At present，the main indexes of iron metabolism are serum iron，total iron binding capacity，serum ferritin.In recent years，a new type of iron regulatory protein （hepcidin） has been discovered.Subsequently，more and more studies showed that hepcidin is an important factor in the level of iron metabolism in uremic hemodialysis patients.This paper mainly from the perspective of laboratory testing reviews the basic theory of uremia disease and the commonly used laboratory tests，at the same time investigates the correlation indexes of iron metabolism and the important role of iron in the patients with uremia. 　　[Key words]Uremia；Iron metabolism；Indicators 　　慢性肾功能衰竭是指各种原发或继发肾脏疾病导致的肾脏功能渐进性不可逆性减退，直至功能丧失所出现的一系列症状和代谢紊乱所组成的临床综合征，简称慢性肾衰。慢性肾衰的终末期即为人们常说的尿毒症。尿毒症不是一个独立的疾病，而是各种晚期的肾脏病共有的临床综合征，是慢性肾衰进入终末阶段时出现的一系列临床表现所组成的综合征[1]。尿毒症常发生进行性肾单位损坏，出现多系统合并症状，临床表现为水、电解质、酸碱平衡失调，以及由于毒素潴留引起的一系列全身中毒症状，病情严重，是威胁人类和健康的主要疾病之一。 　　1慢性肾衰的分期