平均血小板体积与血小板分布宽度联合检测在成人急性肾损伤早期诊断中价值.docVIP

平均血小板体积与血小板分布宽度联合检测在成人急性肾损伤早期诊断中价值 　　[摘要] 目的 探?平均血小板体积（MPV）与血小板分布宽度（PDW）联合检测在成人急性肾损伤早期诊断中的价值。 方法 选取自2016年2月1日～2017年2月1日来我院接收治疗的疑似急性肾损伤早期患者70例，取入院后静脉血分别进行MPV、PDW以及二者联合检测，同时招募40例健康成年人，比较不同疾病分期MPV和PDW的水平，观察不同疾病分期的血栓素、白三烯、血小板活化因子和血小板源性生长因子的表达情况。 结果 MPV、PDW和联合诊断的诊断准确率分别为64.29%、71.43%和87.14%，三种诊断方法灵敏度分别为59.32%、71.19%和84.44%，差异均具有统计学意义（P0.05）。实验组三个分期的MPV和PDW水平均显著高于对照组，差异具有统计学意义（P0.05）。 MPV与AKI临床分期呈正相关关系（r=0.671，P0.05）；PDW与AKI临床分期呈正相关关系（r=0.734，P0.05）；MPV与PDW呈现正相关关系（r=0.377，P0.05）。Ⅱ期和Ⅲ期患者血栓素、白三烯、血小板活化因子，血小板源性生长因子均显著高于Ⅰ期，差异具有统计学意义（P0.05）。 结论 综上所述，MPV和PDW是血小板活化的重要检测指标，在一定程度上反映了血小板功能。目前显示MPV和PDW在某些疾病上能反应疾病严重程度，预测疾病预后。 　　[关键词] 平均血小板体积； 血小板分布宽度； 急性肾损伤； 早期诊断 　　[中图分类号] R692.5 [文献标识码] A [文章编号] 2095-0616（2017）13-215-04 　　[Abstract] Objective To explore the joint detection of value the role of mean platelet volume （MPV） and platelet distribution width （PDW） in adult value in early diagnosis of acute kidney injury. Methods 70 cases of suspected acute kidney injury patients cured in our hospital from February 1th， 2016 to February 1th， 2017 were selected. The venous blood after admission was examined by MPV， PDW， and two methods respectively. 40 healthy adults were recruited at the same time. The different disease staging the level of MPV and PDW were compared. Thee different disease stages of thromboxane， leukotriene， platelet activation factor and the expression of platelet derived growth factor were observed. Results The diagnostic accuracy of MPV， PDW and joint diagnosis were 64.29%， 71.43% and 87.14%， respectively. The diagnosis sensitivity of three methods were 59.32%， 71.19% and 84.44% respectively. The differences were statistically significant （P0.05）. The three stages of the experimental group MPV and PDW were significantly higher than the control group， and the difference was statistically significant （P 　　[Key words] Average platelet volume； The width of the platelet distribution； Acute kidney injury； Early diagnosis 　　急性肾损伤[1-3]（acute kidney injury，AKI）是临床常见的一种综合征，尤