幽门螺杆菌感染与胃食管反流病关系分析.docVIP

幽门螺杆菌感染与胃食管反流病关系分析 　　[摘要] 目的 探讨幽门螺杆菌（Hp）感染与胃食管反流病的关系。 方法 选择本院2014年1月～2016年1月收治的胃食管反流病患者30例，其中正常5例、A?6例、B级9例、C级6例、D级4例，另外选择同期我院消化科经胃镜检查确诊的慢性胃炎伴糜烂患者30例，比较GERD组与胃炎组的Hp感染率以及不同分级GERD患者Hp感染率。 结果 GERD组Hp感染率20.0%，胃炎组Hp感染率60.0%，两组比较差异有统计学意义（P0.05）。结论 幽门螺杆菌（Hp）感染与胃食管反流病具有一定的相关性，Hp感染可能对GERD的发生可能起到一定的保护作用。但由于样本数较少，因此，仍需扩大样本数对Hp感染与GERD关系进行进一步研究，从而为胃食管反流病的临床治疗起到指导性作用。 　　[关键词] 胃食管反流病；幽门螺杆菌；感染；分级 　　[中图分类号] R573.9 [文献标识码] B [文章编号] 1673-9701（2017）13-0082-03 　　[Abstract] Objective To investigate and analyze the relationship between helicobacter pylori （Hp） infection and gastroesophageal reflux disease. Methods 30 patients with gastroesophageal reflux disease who were admitted to our hospital from January 2014 to January 2016 were selected. There were 5 cases of normal， 6 cases of grade A， 5 cases of grade B， 6 cases of grade C， and 8 cases of grade D. In addition， 30 patients with chronic gastritis with erosion diagnosed by endoscopy in the Department of Gastroenterology in our hospital during the same period of time were selected. The Hp infection rate was compared between the GERD group and the gastritis group， and the Hp infection rate in the GERD patients with different grades was compared. Results The infection rate of Hp was 20.0% in GERD group and 60.0% in gastritis group，there was significant difference between the two groups（P0.05）. Conclusion Helicobacter pylori （Hp） infection has a certain correlation with gastroesophageal reflux disease， and Hp infection may have a protective effect on the occurrence of GERD. However， due to the small number of samples， the number of samples should be expanded and further study on the relationship between Hp infection and GERD should be carried out， so as to provide a guiding significance for the clinical treatment of gastroesophageal reflux disease. 　　[Key words] Gastroesophageal reflux disease； Helicobacter pylori （Hp）； Infection； Grading 　　幽门螺杆菌（helicobacterpylori，Hp）是一种从胃黏膜中分离出来的致病菌，研究发现，Hp感染与消化性溃疡、胃癌等胃部疾病具有显著的相关性[1-2]。胃食管反流病（ga