壮医莲花针拔罐逐瘀法治疗变应性鼻炎的临床分析-clinical analysis of zhuang medicine lotus needle cupping and removing blood stasis in the treatment of allergic rhinitis.docxVIP

壮医莲花针拔罐逐瘀法治疗变应性鼻炎的临床研究 中 文 摘 要 目的 ：观察壮医莲花针拔罐逐瘀法对变应性鼻炎鼻炎患者的临床 疗效及作用机制。 方法 ：选择符合现代医学 AR 诊断标准的患者 60 例，随机分为治 疗组和对照组各 30 例，治疗组应用壮医莲花针拔罐逐瘀法治疗，对照组 应用丙酸氟替卡松鼻喷雾剂喷鼻治疗，均以 10 天为 1 疗程，治疗 2 疗程 后观察两组治疗前后总体疗效、主要临床证候、VAS 积分以及相关血清学 指标。 结果 ：（1）两组治疗总体疗效比较差异有统计学意义（P0.001） 治疗组疗效显着优于对照组；（2）在改善喷嚏、流涕、鼻痒、鼻塞等证 候积分方面，治疗组明显优于对照组，两组比较有显着性统计学意义（P 0.05）；（3）治疗组治疗前后 vas 积分经统计学分析改善明显（P0.05）； （4）Th17 细胞的阳性率治疗组和对照组存在明显差异(P0.001)；（5） 治疗后血清 S-IgE 水平治疗组和对照组存在明显差异(P0.001)；（6）两 组治疗前后对肝、肾功能各项，血、尿、粪常规及心电图结果，无明显 异常，显示本治疗方法安全性良好。 结论 ：临床观察结果表明，壮医莲花针拔罐逐瘀法治疗变应性鼻 炎患者疗效显着，尤其在改善主要临床症状和中医证候积分、改善患者 生存质量等方面明显优于西药对照组。对于与变应性鼻炎的发生密切相 关的 Th17 细胞及血清 S-IgE 水平,研究结果显示壮医莲花针拔罐逐瘀法 可以明显降低 Th17 细胞阳性率及血清 S-IgE 水平。在研究过程中未发现 明显不良反应及毒副作用，初步证明了该治疗方法对变应性鼻炎安全、 有效，值得推广应用。 关键词： 壮医莲花针拔罐逐瘀法，变应性鼻炎，Th17 细胞，临床研 究 A clinical research of allergic rhinitis based on Zhuangyi Lianhuazhen Baguan Zhuyu method ABSTRACT Objective：To find out the clinical efficacy and mechanism of Zhuangyi Lianhuazhen Baguan Zhuyu theory on patients of allergic rhinitis. Methods: According to the diagnostic criteria of modern medical AR, 60 eligible patients are randomly and equally divided into two groups: a treatment group and a control group. The treatment group receives acupuncture and cupping Lotus Zhuang medicine treatment of stasis, while the control group receives fluticasone propionate nasal spray treatment. The clinical efficacy, including major clinical syndromes, VAS Score and relative serum markers, of the two groups is discussed in detail prior to and beyond two treatment cycles, where a cycle is 10 days. Results: (1)Statistically (P0.001), the comparison of two groups demonstrates that the clinical efficacy of the treatment group is superior than that of control one. (2)The former has a better effect on improving the sneezing, runny nose, nasal itching, nasal congestion and other syndromes points than the latter whenP0.05; (3)The improving effect on VAS Score in statistics.(4) There is significant difference of Th17 between the treatment and control groups