慢性心力衰竭患者血尿酸与血浆脑钠肽水平变化分析.docVIP

慢性心力衰竭患者血尿酸与血浆脑钠肽水平变化分析 　　[摘要] 目的 探讨慢性心力衰竭患者血尿酸与血浆脑钠肽水平变化规律。 方法 收集2016年9月～2017年1月在我院住院治疗的慢性心力衰竭患者100例为观察组，选择同期来我院进行体检的30例健康就诊者为对照组，比较两组血尿酸与血浆脑钠肽水平变化情况。 结果 随着患者心脏功能级别的增大，患者血尿酸和血浆脑钠肽水平也会随之升高，差异有统计学意义（P0.05），血浆脑钠肽水平和左心室收缩末期内径、左心室舒张末期内径表现为正相关（r1=0.75，r2=0.80），和左心室射血分数呈负相关（r=-0.71）。 结论 慢性心力衰竭患者血尿酸、脑钠肽水平升高，且会随着心功能分级的增加而逐渐提升。 　　[关键词] 慢性心力衰竭患者；血尿酸；血浆脑钠肽水平；变化 　　[中图分类号] R541.6 [文献标识码] A [文章编号] 2095-0616（2017）07-204-03 　　Analysis of serum uric acid and plasma brain natriuretic peptide levels of patients with chronic heart failure 　　PAN Limin 　　Nanhai District Seventh Peoples Hospital，Foshan 528200，China 　　[Abstract] Objective To evaluate the change rule of serum uric acid and plasma brain natriuretic peptide levels of patients with chronic heart failure. Methods 100 cases of patients with chronic heart failure cured in our hospital from September 2016 to January 2017 were selected as the observation group.At the same time，30 cases of medical health patients were selected as control group.The blood uric acid and the change of the level of plasma sodium peptide of the two groups were compared. Results The level of serum uric acid and plasma brain natriuretic peptide （BNP） would increase with the increase of cardiac function.The difference was significant，and it had statistical significance （P0.05）.The plasma level of brain showed positive correlation with left ventricular end systolic diameter，left ventricular end-diastolic diameter （r1=0.75，r2=0.80），and it showed negative correlation with left ventricular ejection fraction （r=-0.71）. Conclusion Serum uric acid and plasma brain natriuretic peptide levels will increase in patients with cardiac function. 　　[Key words] Patients with chronic heart failure；Serum uric acid；Plasma brain natriuretic peptide levels；Change 　　慢性心力衰竭是各?N心脏病发展的结局，为了可以更加有效的对慢性心力衰竭患者进行治疗，需要采取有效的客观指标对慢性心力衰竭患者的心脏功能进行评价。脑钠肽（BNP）作为一种心脏神经激素，在CHF诊断中主要作为实验室检测指标进行应用[1]。而尿酸属于嘌呤代谢的终产物，和各类心血管疾病有着密切的联系，当血清尿酸水平升高时，会导致慢性心力衰竭患者的病情进一步恶化，患者的死亡率也会进一步提升[2]。寻求出一种能早期诊断，准