急性脑梗塞血浆B型脑钠肽前体表达水平及预后相关性分析.docVIP

急性脑梗塞血浆B型脑钠肽前体表达水平及预后相关性分析 　　摘要：目的：探讨急性脑梗塞血浆B型脑钠肽前体表达的差异及预后相关性分析。方法：纳入我院2013年1月至2014年11月确诊为急性脑梗塞的患者100例，对照组50例，观察入院时患者血浆B型脑钠肽前体的表达水平和脑梗塞的情况，根据脑梗塞面积、是否存在意识障碍以及疾病是否好转，再次比较血浆B型脑钠肽前体的表达水平。结果：入院时脑梗塞组血浆B型脑钠肽前体水平高于对照组（P0.05）;大面积脑梗塞组的血浆B型脑钠肽前体水平高于非大面积脑梗塞组（P0.05）;有意识障碍组患者的血浆B型脑钠肽前体表达水平之间明显高于无意识障碍组（P0.05）;死亡组的血浆B型脑钠肽前体水平高于好转组（P0.05）。结论：急性脑梗塞组血浆B型脑钠肽前体水平增加，脑梗塞面积越大、预后越差，血浆B型脑钠肽前体水平越高。血浆B型脑钠肽前体有可能成为急性脑梗塞患者预后的重要指标。 　　关键词：急性脑梗塞;血浆B型脑钠肽前体;预后相关性 　　Abstract： Objective： To explore the differences and prognosis of acute cerebral infarction correlation analysis of plasma B-type natriuretic peptide precursor expression. Methods： Our hospital from January 2013 to November 2014 for the 100 patients diagnosed with acute cerebral infarction， 50 cases in the control group， to observe the situation of plasma B-type expression levels of brain natriuretic peptide precursor after admission and cerebral infarction. Results： admission infarction plasma B-type natriuretic peptide precursor level was higher （P lt;0.05）; plasma B-type natriuretic peptide precursor levels massive cerebral infarction group was higher than non-massive cerebral infarction group （ P lt;0.05）; significantly higher unconscious barriers group （P lt;0.05） between the group of patients with disturbance of consciousness precursor expression levels of plasma B-type natriuretic peptide; plasma levels of B-type natriuretic peptide precursor of brain death was higher than improved group （P lt;0.05）. Conclusion： Acute cerebral infarction plasma B-type natriuretic peptide precursor level increases， the greater the infarction area， the worse the prognosis， the higher plasma B-type natriuretic peptide precursor levels. Plasma B-type natriuretic peptide precursor brain may become an important indicator of prognosis in patients with acute cerebral infarction. 　　Keywords： acute cerebral infarction; plasma B-type natriuretic peptide precursor; Prognosis 　　急性脑梗塞是一种临床常见病和多发病，随着现代人们生活方式和饮食结构的改变，该病的发病率和死亡率不断升高，因此寻找一种判断的疾病发病和预后指标尤为关键[1]。近年