急性脑梗死患者血清标志物P选择素动态测定及临床研究.docVIP

急性脑梗死患者血清标志物P选择素动态测定及临床研究 　　【摘要】 目的 动态观察急性脑梗死(ACI)患者血清P-选择素(P-selectin)的表达特点。并探讨它们与神经功能缺损程度及年龄性别等方面的相关性。方法 应用酶联免疫法(ELISA)动态观察52例ACI患者血清P-selectin的变化,并与52例健康对照者对比,同时应用NIHSS进行神经功能缺损评分。结果 血清P-selectin 在ACI发病后早期显著高于正常对照组(P0.05)。血清P-selectin 水平与临床神经功能缺损程度评分无相关性。结论 ACI早期存在血小板活化、它参与了脑组织的缺血性损伤,形成脑梗死早期的发病基础,并参与急性脑梗死的病理生理过程。P-selectin 虽然参与发病,但不能预测ACI的致残性和近期预后。 　　【关键词】 急性脑梗死;P-选择素;神经功能缺损评分 　　 　　Correlative study and serially assay of P-selectinin patients with acute cerebral infarction 　　 　　CHANG Hui-jun, ZHANG Qi-xiang, LU Hong,et al. 　　The Central Hospital of Xinxiang City;Department of Neurology,the Second Affiliated Hospital of Xiuxaing Medical College,Henan 45300,China 　　 　　【Abstract】 Objective To study the serial changes of the expression of P-selectinconcentrations in serum from patients with acute cerebral infarction (ACI) and to find the correlations with neurological deficits of ACI, sex and age etc. Methods The P-selectin concentrations were serially determined in the 52 inpatients with ACI and 52 control subjects. Assays were performed by using enzyme linked immunosorbent assay (ELISA). At the same time the neurological deficits states were evaluated by the national institute of health stroke scale (NIHSS).Results The levels of serum P-selectinin patients with ACI within 15 days after the onset were significantly higher than that in normal controls (P0.05). The releases of P-selectin in patients after ischemic stroke were not associated with the neurological outcome as assessed by NIHSS. Peaked concentrations of P-selectin were not associated with the sex and age etc. Conclusion Platelet activations were observed in patients with ACI. It was involved in cerebral ischemic injury. It could be the basis of early ACI pathogenesis and participates in the differential pathogenesis process of ACI. Although P-selectin participated in the pathogenesis, it could not predict the disability of ACI and its prognosis in the near future. 　　【Key words】 Acute cerebral in