戊二醛对比酒精用于青霉素皮试消毒Meta分析.docVIP

戊二醛对比酒精用于青霉素皮试消毒Meta分析 　　[摘要]目的 评价国内已发表的文献中戊二醛清洁对比酒精消毒对青霉素皮试结果的影响。方法 检索中国生物医学文献数据库（CBM）、中国期刊全文数据库（CNKI）、维普、万方、PubMed、Cohrance数据库等数据库，查找关于戊二醛对比酒精消毒用于青霉素皮试的的随机对照试验（RCT）。检索时间从建库截止到2017年1月。根据评价研究质量决定纳入与排除标准筛选文献。采用RevMan 5.0软件进行Meta分析。结果 检索得到113篇文献，有4篇文献符合纳入标准。Meta分析示，各组研究的异质性I2=0%，OR值为0.16（95%CI=0.11～0.22）（P0.00001），但发表偏倚可能使结果夸大戊二醛的作用。结论 戊二醛对比酒精消毒用于青霉素皮试的假阳性率较低，戊二醛是否可代替酒精用于青霉素皮试消毒尚需进一步证实。由于纳入研究的质量不高，上述结论尚需开展更多高质量的随机双盲对照试验加以验证。 　　[关键词]戊二醛；青霉素；皮试，皮内注射；Meta分析 　　[中图分类号] R472.1 [文献标识码] A [文章编号] 1674-4721（2017）10（c）-0008-03 　　Meta-analysis of Glutaraldehyde vs Ethanol for disinfection of Penicillin skin test 　　LI Xia-xi1 LIU Cui-ping1 LIU Xing-xing1 DU Meng1 FU Cai-yan2▲ 　　1.Department of ICU，Zhujiang Hospital of Southern Medical University，Guangdong Province，Guagnzhou 510280，China；2.Department of Endocrinology，Affiliated Hospital of Guangdong Medical University，Guangdong Province，Zhanjiang 524000，China 　　[Abstract]Objective To evaluate the influence of Glutaraldehyde cleaning vs Ethanol disinfection on Penicillin skin test result in the published literatures in China.Methods Randomized controlled trials （RCT） in Glutaraldehyde vs Ethanol applied in Penicillin skin test were searched and screened in CBM，CNKI，VIP，Wanfang，PubMed，Cohrance database and so on.The retrieval time was from database building to January，2017.The literature was screened according to the inclusion and exclusion criteria decided by the evaluation research quality.Meta-analysis was conducted using Review Manager 5.0 software.Results Totally 4 studies were eligible to the criteria in 113 literatures reviewed.Meta-analysis showed there was significant difference between Glutaraldehyde and Ethanol groups：I2=0% （OR=0.16，95%CI=0.11-0.22，P0.00001），but publication bias may exaggerate the effect of Glutaraldehyde.Conclusion Glutaraldehyde has lower false positive rate compared with Ethanol，but further studies are needed in proving whether Glutaraldehyde can replace Ethanol in penicillin skin test.The quali