比较分析奥曲肽垂体后叶素治疗肝硬化上消化道出血疗效.docVIP

比较分析奥曲肽垂体后叶素治疗肝硬化上消化道出血疗效 　　[摘要] 目的 对比分别应用奥曲肽与垂体后叶素对肝硬化上消化道出血患者进行治疗可以取得的临床疗效。 方法 选取该院近来3年收治的肝硬化上消化道出血患者200例，随机将其分为A、B两组，对比A、B两组患者的临床疗效。 结果 A组患者的总有效率为99%，B组患者的总有效率为70%，A组临床疗效显著优于B组，此外，A组患者不良反应发生率为5%，B组患者的不良反应发生率为52%，A组明显低于B组，两者的差异有统计学意义（P0.05）。 结论 应用奥曲肽对肝硬化上消化道出血患者进行治疗，其临床疗效明显优于垂体后叶素，并且不良反应出现几率也很低，值得各大医院推广应用。 　　[关键词] 奥曲肽；垂体后叶素；肝硬化上消化道出血；临床疗效对比 　　[中图分类号] R575.2 [文献标识码] A [文章编号] 1674-0742（2014）07（a）-0021-02 　　[Abstract] Objective To compare the clinical curative effect between octreotide and pituitrin on liver cirrhosis patients with upper gastrointestinal bleeding. Methods 200 cases of liver cirrhosis patients with upper gastrointestinal hemorrhage admitted in our hospital in recent 3 years were selected and randomly divided into A group and B group， the clinical efficacy of the two groups was compared. Results The total effective rate of the patients in A group was 99%， and that of the patients in B group was 70%， the clinical curative effect of A group was higher than that of B group. In addition， the incidence of adverse reactions of the patients in A group was 5%， and that of B group was 52%， the incidence of adverse reactions of A group was significantly lower than that of B group， the difference between them was statistical significant（P0.05）. Conclusion For patients with cirrhosis and upper gastrointestinal hemorrhage， the clinical curative effect of octreotide is obviously better than that of pituitrin with lower incidence of adverse reactions， which is worthy of popularization and application in hospitals. 　　[Key words] Octreotide； Pituitrin； Cirrhosis with upper gastrointestinal hemorrhage； Comparison of clinical efficacy 　　终末期肝病并发症中，上消化道出血具有极高的发病率，如果治疗被厌恶，会危害到患者的生命安全，情况过于严重时还可以直接导致患者死亡[1]。为了探讨应用奥曲肽与垂体后叶素两者治疗肝硬化上消化道出血的临床疗效，该研究对该院于2011年9月―2013年9月间分别对肝硬化上消化道出血患者使用奥曲肽、垂体后叶素治疗，并且对比两组的临床疗效，现对其进行分析，报告如下。 　　1 资料与方法 　　1.1 一般资料 　　选取前往该院进行治疗的肝硬化上消化道出血患者200例，随机将其分为A、B两组，其中A组100例，男性60例，女性40例；年龄29～81岁，平均年龄为（53.23±1.76）岁；根据肝功能临床分级划分：A级30例，B级45例，C级25例。B组100例，男性50