检测凝血功能和血小板计数对肝硬化患者临床意义.docVIP

检测凝血功能和血小板计数对肝硬化患者临床意义 　　【摘要】 目的 探讨凝血功能[凝血酶原时间 （PT）、活化部分凝血活酶时间（APTT）]和血小板计数（PLT） 对于肝硬化患者的?R床意义。方法 选取同期的55例肝硬化患者（肝硬化组）与50例正常体检者（对照组）， 比较分析肝硬化组于对照组及肝硬化是否出血患者的外周血 PT、 APTT、PLT水平。结果 肝硬化组患者的PT（21.40±3.98）s、APTT（52.05±5.73）s长于对照组的（10.20±1.02）s、（32.46±2.58）s， PLT（57.29±16.57）×109/L低于对照组的（197.42±32.48）×109/L， 差异具有统计学意义（t=19.322、22.208、-28.219， P0.01）。肝硬化患者中出血患者PLT（48.29±19.57）×109/L较未出血患者的（68.42±10.26）×109/L少， 且PT（23.40±4.63）s、APTT（60.05±3.04）s明显较未出血患者的（17.20±8.03）s、（46.01±9.44）s长， 差异均具有统计学意义（t=-4.975、2.810、-8.848， P0.01）。结论 凝血功能及血小板对于衡量肝硬化患者出血倾向和预后判断有重要意义， 值得推广。 　　【关键词】 凝血功能；血小板计数；肝硬化 　　DOI：10.14163/j.cnki.11-5547/r.2017.17.023 　　Clinical significance of blood coagulation function and blood platelet count for liver cirrhosis patients WU Kun， ZHANG Dong-xia. Department of Gastroenterology， First Affiliated Hospital of Baotou Medical College of Inner Mongolia University of Science and Technology， Baotou 014010， China 　　【Abstract】 Objective To investigate clinical significance of blood coagulation function [prothrombin time （PT）， activated partial thromboplastin time （APTT）] and blood platelet count （PLT） for liver cirrhosis patients. Methods There were 55 patients with liver cirrhosis （liver cirrhosis group） and 50 healthy people in physical examination （control group） at the same period. Comparison and analyze were made on peripheral blood PT， APTT and PLT level in liver cirrhosis group， control group， and liver cirrhosis patients with hemorrhage. Results The liver cirrhosis group had longer PT as （21.40±3.98） s and APTT as （52.05±5.73） s than （10.20±1.02） s and （32.46±2.58） s in the control group， and it also had lower PLT as （57.29±16.57）×109/L 　　than （197.42±32.48）×109/L in the control group， and their difference had statistical significance （t=19.322， 22.208， -28.219， P0.01）. Liver cirrhosis patients with hemorrhage had lower PLT as （48.29±19.57）×109/L than （68.42±10.26）×109/L in those without hemorrhage， and they also had obviously longer PT as （23.40±4.63） s