枳实―白芍药对干预肝郁脾虚型IBS大鼠配伍及药效学研究.docVIP

枳实―白芍药对干预肝郁脾虚型IBS大鼠配伍及药效学研究 　　【摘要】 目的：研究枳实、白芍不同配比对肝郁脾虚型IBS大鼠肠道的影响，探讨枳实-白芍药对干预肝郁脾虚型IBS大鼠的配伍及药效学特点。方法：选取48只大鼠，随机平均分为8组，分别采用生理盐水、0.025g/kg匹维溴铵溶液、不同比例枳实-白芍溶液灌胃6 g/kg，对各组大鼠的小肠推进率、粪点数、体重进行比较。结果：不同配比枳实-白芍对肝郁脾虚型IBS大鼠排便、体重均有影响。结论：枳实-白芍对肝郁脾虚型IBS大鼠具有干预作用。 　　【关键词】 枳实； 白芍； 肝郁脾虚； IBS； 配伍 　　Pharmacodynamics of Fructus Aurantii Immaturus-Radix Paeoniae Alba Herb-Pair in IBS Rats with Stagnation of Liver and Spleen Deficiency/LUO Chun-hua，LUO Qian，HUANG Yun-ying.//Medical Innovation of China，2016，13（22）：021-024 　　【Abstract】 Objective：To explore the changes in the chemical composition of Fructus Aurantii Immaturus-Radix Paeoniae Alba herb-pair， the dose-effect relationship， the change of the pharmacological effects and metabolic mechanisms and compatibility discipline in vivo.Method：48 SD rats were randomly divided into 8 groups，they were respectively given normal saline，0.025 g/kg Pinaverium Bromide solution，irrigation stomach to IBS rats with different compatibility ratio of 6 g/kg，the small intestinal propulsion rates， the amount of defecation in 24 h， weight and intestinal sensitivity were observed as pharmacologic index.Result：It was found that Fructus Aurantii Immaturus-Radix Paeoniae Alba herb-pairs of different compatibility ratio significantly decreased defecation number and increased the growth rate of body weight.Conclusion： Fructus Aurantii Immaturus- Radix Paeoniae Alba has intervention effect on stagnation of liver and spleen deficiency IBS rats. 　　【Key words】 Fructus Aurantii Immaturus； Radix Paeoniae Alba； Stagnation of liver and spleen deficiency； IBS； Compatibility 　　First-author’s address：The Fifth Affiliated Hospital of Guangzhou Medical University，Guangzhou 510700，China 　　doi：10.3969/j.issn.1674-4985.2016.22.005 　　肠易激综合征（IBS）是临床常见胃肠道功能紊乱疾病，以腹痛、腹泻和腹部不适为主要临床改变。患者多存在大便性状改变、次数增多表现，患者的症状随排便减轻[1-2]。IBS具有病程长、易反复特点，严重降低患者的生活质量，也给患者带来沉重的经济和心理负担。目前西医缺乏治疗IBS的特效药物，中医临床研究报道枳芍散治疗IBS的优势明显，中医认为IBS主要病机为肝郁脾虚，应根据调和肝脾、疏肝健脾原则用药[3-4]。因此，本文建立肝郁脾虚型IBS大鼠模型，使用枳实―白芍干预大鼠模型，分析枳实―白芍对