枸地氯雷他定不同剂量方案治疗慢性荨麻疹效果对比.docVIP

枸地氯雷他定不同剂量方案治疗慢性荨麻疹效果对比 　　[摘要]目的 ?Ρ辱鄣芈壤姿?定不同剂量方案治疗慢性荨麻疹的效果。方法 将我院2016年1～6月门急诊和皮肤科就诊的62例慢性荨麻疹患者按照随机数字表法分为观察组和对照组各31例，观察组患者给予枸地氯雷他定递减用药方法治疗，对照组患者给予枸地氯雷他定常规用药方法治疗。观察两组患者治疗前后临床症状评分，比较两组患者治疗效果、治疗前后血清IgE水平改变，记录两组患者不良反应及复发情况。结果 两组患者治疗后瘙痒程度、风团大小、风团数目及持续时间症状评分均较治疗前显著降低（P0.05）；停药后4周观察组患者IgE水平较治疗后无明显升高（P0.05），而对照组患者IgE水平较治疗后显著升高（P0.05）。观察组患者复发率为19.35%，显著低于对照组的48.39%，差异有统计学意义（P0.05）。结论 枸地氯雷他定递减疗法可在改善症状的同时显著提高治疗有效率，改善血清IgE水平并降低复发率。 　　[关键词]枸地氯雷他定；常规疗法；递减疗法；慢性荨麻疹 　　[中图分类号] R758.24 [文献标识码] A [文章编号] 1674-4721（2017）01（c）-0061-04 　　[Abstract]Objective To compare the clinical effect of different dosage regimen of Desloratadine citrate disodium in treating chronic urticaria.Methods A total of 62 patients with chronic urticaria who were treated in our hospital from Jannary to June 2016 were enrolled in and divieded into observation group and control group according to random number table method，with 31 patients in each group.Patients in the observation group were given decremental treatment of Desloratadine citrate disodium，while patients in the control group were given conventional treatment.The clinical symptom score，clinical effect，level of serum IgE，adverse reaction rate and recurrence rate of two groups were recorded and compared.Results Clinical symptom scores of pruritus，wheal size，wheal number and duration after treatment in two groups were significantly lower than those before treatment （P0.05）；4 weeks after withdrawal，level of IgE in the observation group was not significantly higher than that after treatment （P0.05），while level of IgE in the control group was significantly increased than that after treatment （P0.05）.Recurrence rate in the observation group was 19.35%，significantly lower than 48.39% in the control group，and the difference was statistically significant （P 　　[Key words]Desloratadine citrate disodium；Conventional treatment；Decremental treatment；Chronic urticaria 　　慢性荨麻疹是一种常见的由各种原因引起的反复发作6周的异质性疾病，其病理改变是皮肤黏膜血管暂时性组织水肿或炎性充血，发作时间不定，患者瘙痒感明显，生活质量受到严重影响[1-2]。枸地氯雷他定