特重型颅脑损伤患者早期应用机械通气临床研究.docVIP

特重型颅脑损伤患者早期应用机械通气临床研究 　　【摘要】 目的：研究特重型颅脑损伤患者早期进行机械通气对预后的影响。方法：选取2009年2月-2013年2月因各种原因导致的86例特重型颅脑损伤患者作为研究对象，按照随机数字表法将其分为观察组52例和对照组 　　34例。观察组在颅脑损伤后及时进行机械通气，对照组在颅脑损伤后先通过吸氧治疗，在出现明显的呼吸功能障碍甚至呼吸衰竭时进行机械通气治疗。比较两组通气前后PaO2、PaCO2、SaO2、HR、BP等观察指标，并对两组GCS评分、LIS评分以及随访结果进行分析。结果：两组患者通气前后各项观察指标比较差异均有统计学意义（P0.05）；且观察组通气后的各项观察指标与对照组通气后比较，差异均有统计学意义（P0.05）。经过6个月随访后，观察组的死亡率13.46%明显低于对照组的44.12%，差异有统计学意义（ 字2=10.579，P=0.032）。结论：特重型颅脑损伤患者尽早机械通气能显著改善患者缺氧，减轻颅内压，对预后有重要的积极作用。 　　【关键词】 特重型； 颅脑损伤； 早期； 机械通气； 临床研究 　　Clinical Study of Early Application of Mechanical Ventilation in Patients with Severe Craniocerebral Injury/CHEN Peng.//Medical Innovation of China，2015，12（20）：054-056 　　【Abstract】 Objective：To study the effect of early mechanical ventilation in severe craniocerebral injury patients on prognosis.Method：86 patients with severe craniocerebral injury caused by various reasons from February 2009 to February 2013 in our hospital were selected as research objects，they were divided into the observation group for 52 cases and the control group for 34 cases.The observation group was given mechanical ventilation after craniocerebral injury，and the control group was treated with oxygen therapy first，when the apparent respiratory dysfunction and respiratory failure，they were given mechanical ventilation.The PaO2，PaCO2，SaO2，HR，BP，GCS score，LIS score and the follow-up results before and after mechanical ventilation of the two groups were analyzed and compared.Result：The observed indicators before and after mechanical ventilation of the two groups had statistical significance differences（P0.05）.The observed indicators after mechanical ventilation in the observation group compared with the control group，the differences were statistically significant（P0.05）.After 6 months of follow-up，the mortality rate of the observation group was 13.46%，which was significantly lower than 44.12% of the control group，the difference was statistically significant（ 字2=10.579，P=0.032）.Conclusion：Severe craniocerebral injur