神经节苷脂联合依达拉奉治疗急性一氧化碳中毒迟发型脑病临床观察.docVIP

神经节苷脂联合依达拉奉治疗急性一氧化碳中毒迟发型脑病临床观察 　　【摘要】 目的：探讨神经节苷脂联合依达拉奉治疗一氧化碳中毒迟发型脑病的临床疗效。方法：将本科收治的87例一氧化碳中毒迟发性脑病患者随机分为对照组（n=42）及试验组（n=45），两组均接受高压氧、抗血小板聚集、改善微循环、促进脑代谢等常规治疗；试验组在此基础上加用神经节苷脂及依达拉奉治疗，观察两组患者的治疗效果，采用简易智力状态量表（MMSE）和改良Barthel指数（MBI）量表评价两组患者治疗前、后的认知功能和日常生活活动能力。结果：对照组治疗总有效率为76.2%，试验组为93.3%，差异有统计学意义（P0.05）。与治疗前相比，两组治疗后的MMSE评分、MBI评分均明显提高（P0.05）；与治疗后的对照组相比，试验组治疗后MMSE评分、MBI评分也有明显提高（P0.05）。结论：神经节苷脂联合依达拉奉治疗一氧化碳中毒迟发型脑病，可明显改善患者的预后，并明显改善患者的认知能力和日常生活能力。 　　【关键词】 神经节苷脂； 依达拉奉； 迟发性脑病； 有效率； MMSE； MBI 　　Clinical Observation of Ganglioside Plus Edaravone in the Treatment of Delayed Encephalopathy after Acute Carbon Monoxide Poisoning/SU Li-jun，LIU Yu-fa，GAO Li，et al.//Medical Innovation of China，2015，12（26）：001-003 　　【Abstract】 Objective：To study the efficiency of Ganglioside plus Edaravone in the treatment of delayed encephalopathy after acute carbon monoxide poisoning.Method：87 cases of delayed encephalopathy caused by carbon monoxide poisoning admitted to our department， were randomly divided into two groups：the control group （n=42） was given conventional hyperbaric oxygen，preventing platelet aggregation，improving microcirculation，improving cerebral metabolism and other conventional treatment；the experimental group （n=45） was given Ganglioside （100 mg， intravenous drip 1/d）， Edaravone （30 mg， intravenous drip 2 /d） for 21 days on the basis of the control group. The efficiency of two groups were observed and their cognitive function and daily life activity with the mini-mental state examination （MMSE） and modified Barthel index （MBI） before treatment and after treatment were evaluated.Result：The efficiency of the control group was 76.2%， the efficiency of the experimental group was 93.3%（P0.05）. MMSE score and MBI score of the control group and experimental group after treatment were higher than those of before treatment（P0.05）；MMSE score and MBI score of the experimental group were obviously higher than those of the control group after treatment（P0.05）.Conclusion：Application of Ganglio