米索前列醇联合乳头刺激在妊娠晚期促宫颈成熟中运用.docVIP

米索前列醇联合乳头刺激在妊娠晚期促宫颈成熟中运用 　　[摘要] 目的 观察米索前列醇联合乳头刺激在妊娠晚期促宫颈成熟中的效果及安全性。 方法 选取2015年1～12月在我院妇产科住院有引产指征而无禁忌证的孕妇120例，随机分成三组，实验组60例，给予米索前列醇25 μg阴道后穹窿放置后2 h配合乳头刺激，对照1组30例，单用米索前列醇25 μg阴道后穹窿放置，对照2组30例，单采用乳头刺激。观察其在促宫颈成熟、分娩结局及新生儿结局方面的效果。 结果 实验组促宫颈成熟总有效率为93.3%，阴道分娩率为81.7%，较对照组明显增高，差异有统计学意义（P0.05）。各组之间羊水污染及新生儿窒息率发生率均较低，差异无统计学意义（P0.05）。 结论 米索前列醇联合乳头刺激是一种安全有效的促宫颈成熟方法，特别适合于有监测手段的基层医院使用。 　　[关键词] 米索前列醇；乳头刺激；妊娠；宫颈成熟 　　[中图分类号] R714 [文献标识码] B [文章编号] 1673-9701（2016）13-0070-03 　　Application of misoprostol combined with nipple stimulation in promotion of cervical ripening in late trimester of pregnancy 　　LIU Yan CHEN Bin LI Zhiping ZHOU Jian 　　Department of Obstetrics， Jiangxi Province Fuzhou City Maternity and Childrens Health Care Centers， Fuzhou 344000， China 　　[Abstract] Objective To observe the effect and safety of misoprostol combined with nipple stimulation in promotion of cervical ripening in late trimester of pregnancy. Methods 120 pregnant women with induced labour indications and without contraindications in our department from January to December 2015 were selected and randomly divided into 3 groups. The 60 women in study group were given misoprostol of 25 μg placed at posterior fornix， and after 2 hours， they were additionally given nipple stimulation. The 30 women in control group 1 were only given misoprostol of 25 μg placed at posterior fornix and the 30 women in in control group 2 were only given nipple stimulation. The effects on promotion of cervical ripening， delivery outcome， and neonatal outcome were observed. Results In the study group， the effective rate was 93.3%， the rate of vaginal delivery was 81.7%， which were significantly higher than those in the control groups （P0.05）. Incidence rates of amniotic fluid pollution and neonatal asphyxia were low in all groups and without significant difference（P0.05）. Conclusion Misoprostol combined with nipple stimulation is safe and effective in promotion of cervical ripening， which is suited for primary hospitals with m