肝病与胆汁反流性胃炎关系分析.docVIP

肝病与胆汁反流性胃炎关系分析 　　[摘要] 目的 探讨非酒精性脂肪肝（NAFLD）、肝硬化及肝癌与胆汁反流性胃炎（BRG）的关系。 方法 选取2010年1月～2013年12月本院的155例NAFLD、133例肝炎后或酒精性肝硬化及95例肝细胞癌患者作为研究对象，同时选取157例无肝脏疾病的健康人作为对照组，回顾性分析和比较以上各组及不同肝功能CTP分级中的BRG发生率。 结果 不同组别的BRG发生率比较，差异有统计学意义（χ2=16.010，P0.05）。NAFLD组、肝硬化组、肝癌组的BRG发生率显著高于对照组，差异有统计学意义（P0.05）。不同CTP分级的BRG发生率比较，差异有统计学意义（χ2=10.933，P0.05）。B级与C级的BRG发生率显著高于A级，差异有统计学意义（P0.05）。 结论 非酒精性脂肪肝、肝炎后或酒精性肝硬化及肝细胞癌患者较正常人容易发生胆汁反流性胃炎。 　　[关键词] 非酒精性脂肪肝；肝硬化；肝癌；胆汁反流性胃炎 　　[中图分类号] R575 [文献标识码] A [文章编号] 1674-4721（2015）05（c）-0037-03 　　[Abstract] Objective To explore the relationship between non-alcoholic fatty liver disease （NAFLD），hepatocirrhosis，hepatocellular carcinoma and bile reflux gastritis （BRG）. Methods 155 patients with NAFLD，133 patients with hepatic and alcoholic hepatocirrhosis，95 patients with hepatocellular carcinoma from January 2010 to December 2013 in our hospital were selected as the research objects，157 healthy people were selected as the control group.The morbidity rates of BRG were retrospectively analyzed and compared in all above groups and in different CTP grade groups. Results The incidence rate of BRG in different groups was statistically significant（χ2=16.010，P0.05）.The incidence rate of BRG in the NAFLD group，the hepatocirrhosis group，the hepatocellular carcinoma group was higher than that in the control group，with significant difference（P0.05）.The incidence rate of BRG in different CTP grade was statistically significant（χ2=10.933，P0.05）.The incidence rate of BRG in grade B and grade C was higher than that in grade A，with significant difference（P0.05）. Conclusion The BRG is prone to the patients with nonalcoholic fatty liver，hepatitis or alcoholic cirrhosis and hepatocellular carcinoma.. 　　[Key words] Non-alcoholic fatty liver disease；Hepatocirrhosis；Hepatocellular carcinoma；Bile reflux gastritis 　　胆汁反流性胃炎（bile reflux gastritis，BRG）是由于含有胆汁及胰液的十二指肠液向胃内反流导致胃黏膜出现慢性炎症性改变的疾病，为消化系统多发病之一，多与胃部分切除术、胆囊疾病、糖尿病、消化性溃疡、胰腺炎、消化道肿瘤有关，目前有关肝病与胆汁反流性胃炎的相关性研究较少。本研究对近年来在本院就诊的临床病例进行回顾性分析，旨在探讨非酒精性脂肪肝（