肺表面活性物质联合机械通气治疗新生儿呼吸窘迫综合征临床研究.docVIP

肺表面活性物质联合机械通气治疗新生儿呼吸窘迫综合征临床研究 　　[摘要] 目的 研究对比单独应用机械通气和联合应用肺表面活性物质及机械通气治疗新生儿呼吸窘迫综合征（NRDS）的疗效。 方法 90例患儿随机分为观察组和对照组。对照组行机械通气治疗；观察组在对照组机械通气治疗基础上加肺表面活性物质治疗。 结果 对照组患儿治愈率为62.2%，观察组治愈率为93.3%。治疗后观察组患儿的各项指标明显优于对照组患儿，差异有统计学意义（P ＜ 0.05）。 结论 机械通气联合肺表面活性物质治疗新生儿呼吸窘迫综合征，有优势互补作用，能快速有效改善患儿呼吸症状，有效地提高治愈率，值得推广。 　　[关键词] 新生儿呼吸窘迫综合征；肺表面活性物质；机械通气；疗效 　　[中图分类号] R722.1 [文献标识码] A [文章编号] 1674-4721（2012）02（a）-0023-02 　　 　　The clinical research of lung surface active material unite mechanical entilation treat 90 cases neonatal respiratory syndrome 　　TAN Jing 　　Xiangtan Central Hospital in Hunan Province, Xiangtan 411100, China 　　[Abstract] Objective To compare the curative effect about using alone mechanical entilation and combined application of mechanical entilation and lung surface active substances to treat neonatal respiratory distress syndrome (NRDS). Methods Ninety cases of NRDS patients were randomly divided into trial group and control group. The patients of the control group did mechanical ventilation treatment; the patients of the observation group did PS treatment on the base of mechanical ventilation treatmention. Results The cure rate of the control group was 62.2% and the observation group was 93.3%; after the treatment, the various indexes of the observation group was much better than the control group, the difference was statistically significant (P ＜ 0.05). Conclusion To treat neonatal respiratory distress syndrome, the combination treatment of mechanical entilation and lung surface active material have complementary advantages effect, can quickly and effectively improve respiratory symptoms and cure rate, is worthy to be popularized. 　　[Key words] Neonatal respiratory distress syndrome; Lung surface active substances; Mechanical ventilation; Effect 　　 　　新生儿呼吸窘迫综合征（NRDS）是一种常见的新生儿危重症，多见于早产儿，主要表现是出生后不久出现呼吸窘迫并呈进行加重，是导致新生儿死亡的主要原因之一[1]。近年来，由于机械通气的普及使用，为NRDS治疗提供了新的方法，使治愈率大为提高。笔者针对90例应用PS联合机械通气治疗的NRDS患儿进行了分析研究，现汇报如下： 　　1对象与方法 　　1.1研究对象 　　2007年1月~2011年6月在本院新生儿科住院的90例NRDS患儿，